Requirements for immune recognition and processing of factor VIII by antigen-presenting cells

Simon D. van Haren; Aleksandra Wroblewska; Kathelijn Fischer; Jan Voorberg; Eszter Herczenik

doi:https://doi.org/10.1016/j.blre.2011.10.001

Requirements for immune recognition and processing of factor VIII by antigen-presenting cells

Simon D. van Haren, Aleksandra Wroblewska, Kathelijn Fischer, Jan Voorberg, Eszter Herczenik

Landsteiner Laboratory (AMC)

Research output: Contribution to journal › Review article › Academic › peer-review

16 Citations (Scopus)

Abstract

Generation of inhibitory antibodies upon repeated FVIII infusion represents a major complication in hemophilia care. Professional antigen presenting cells (APCs) are crucial for orchestration of humoral immune responses. APCs are capable of internalizing soluble as well as particulate antigens through various mechanisms resulting in loading of antigen-derived peptides on MHC class I or II for presentation to T cells. This review highlights how FVIII is recognized and processed by APCs. The significance and contribution of candidate receptors involved in FVIII uptake by APC are discussed. Recent findings defining the repertoire of FVIII peptides presented on MHC class II are addressed. Studies in murine models of hemophilia A suggest that modulation of APC function can reduce inhibitor formation. Based on this we anticipate that modulation of FVIII uptake by APCs may yield novel therapeutic approaches for treatment or prevention of inhibitor formation in patients with hemophilia A. (C) 2011 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	43-49
Journal	Blood Reviews
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.blre.2011.10.001
Publication status	Published - 2012

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https://doi.org/10.1016/j.blre.2011.10.001

Cite this

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title = "Requirements for immune recognition and processing of factor VIII by antigen-presenting cells",

abstract = "Generation of inhibitory antibodies upon repeated FVIII infusion represents a major complication in hemophilia care. Professional antigen presenting cells (APCs) are crucial for orchestration of humoral immune responses. APCs are capable of internalizing soluble as well as particulate antigens through various mechanisms resulting in loading of antigen-derived peptides on MHC class I or II for presentation to T cells. This review highlights how FVIII is recognized and processed by APCs. The significance and contribution of candidate receptors involved in FVIII uptake by APC are discussed. Recent findings defining the repertoire of FVIII peptides presented on MHC class II are addressed. Studies in murine models of hemophilia A suggest that modulation of APC function can reduce inhibitor formation. Based on this we anticipate that modulation of FVIII uptake by APCs may yield novel therapeutic approaches for treatment or prevention of inhibitor formation in patients with hemophilia A. (C) 2011 Elsevier Ltd. All rights reserved",

author = "{van Haren}, {Simon D.} and Aleksandra Wroblewska and Kathelijn Fischer and Jan Voorberg and Eszter Herczenik",

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T1 - Requirements for immune recognition and processing of factor VIII by antigen-presenting cells

AU - van Haren, Simon D.

AU - Wroblewska, Aleksandra

AU - Fischer, Kathelijn

AU - Voorberg, Jan

AU - Herczenik, Eszter

PY - 2012

Y1 - 2012

N2 - Generation of inhibitory antibodies upon repeated FVIII infusion represents a major complication in hemophilia care. Professional antigen presenting cells (APCs) are crucial for orchestration of humoral immune responses. APCs are capable of internalizing soluble as well as particulate antigens through various mechanisms resulting in loading of antigen-derived peptides on MHC class I or II for presentation to T cells. This review highlights how FVIII is recognized and processed by APCs. The significance and contribution of candidate receptors involved in FVIII uptake by APC are discussed. Recent findings defining the repertoire of FVIII peptides presented on MHC class II are addressed. Studies in murine models of hemophilia A suggest that modulation of APC function can reduce inhibitor formation. Based on this we anticipate that modulation of FVIII uptake by APCs may yield novel therapeutic approaches for treatment or prevention of inhibitor formation in patients with hemophilia A. (C) 2011 Elsevier Ltd. All rights reserved

AB - Generation of inhibitory antibodies upon repeated FVIII infusion represents a major complication in hemophilia care. Professional antigen presenting cells (APCs) are crucial for orchestration of humoral immune responses. APCs are capable of internalizing soluble as well as particulate antigens through various mechanisms resulting in loading of antigen-derived peptides on MHC class I or II for presentation to T cells. This review highlights how FVIII is recognized and processed by APCs. The significance and contribution of candidate receptors involved in FVIII uptake by APC are discussed. Recent findings defining the repertoire of FVIII peptides presented on MHC class II are addressed. Studies in murine models of hemophilia A suggest that modulation of APC function can reduce inhibitor formation. Based on this we anticipate that modulation of FVIII uptake by APCs may yield novel therapeutic approaches for treatment or prevention of inhibitor formation in patients with hemophilia A. (C) 2011 Elsevier Ltd. All rights reserved

U2 - https://doi.org/10.1016/j.blre.2011.10.001

DO - https://doi.org/10.1016/j.blre.2011.10.001

M3 - Review article

C2 - 22036515

SN - 0268-960X

VL - 26

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