Abstract
Necrotizing autoimmune myopathy (NAM) is a rare variant of idiopathic inflammatory myopathies associated with various underlying conditions. We describe a 48-year-old woman with a history of breast cancer who presented with acute respiratory failure and progressive loss of strength in her limb muscles over a period of two months. Muscle biopsy was consistent with necrotizing myopathy. No signs of active tumour were found. Immunoblot was positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies. Based on the subacute onset and muscle biopsy a diagnosis of NAM was made. Treatment with immunosuppressive and immunomodulating therapy led to almost complete recovery. Respiratory insufficiency as a presenting symptom of NAM is unusual. Recognition of this manifestation is crucial as early and aggressive treatment can lead to substantial recovery.
Original language | English |
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Pages (from-to) | 457-460 |
Number of pages | 4 |
Journal | Neuromuscular disorders |
Volume | 25 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2015 |
Keywords
- Autoimmune
- Myositis specific antibodies
- Necrotizing myopathy
- Paraneoplastic myopathy
- Respiratory insufficiency