TY - JOUR
T1 - Right-to-Left Ventricular Diastolic Delay in Chronic Thromboembolic Pulmonary Hypertension Is Associated With Activation Delay and Action Potential Prolongation in Right Ventricle
AU - Hardziyenka, Maxim
AU - Campian, Maria E.
AU - Bouma, Berto J.
AU - Linnenbank, André C.
AU - de Bruin-Bon, H. A. C. M. Rianne
AU - Kloek, Jaap J.
AU - van der Wal, Allard C.
AU - Baan, Jan
AU - de Beaumont, Edouard M.
AU - Reesink, Herre J.
AU - de Bakker, Jacques M. T.
AU - Bresser, Paul
AU - Tan, Hanno L.
PY - 2009
Y1 - 2009
N2 - Background-Delayed left ventricle (LV)-to-right ventricle (RV) peak shortening results in cardiac output reduction in patients with chronic thromboembolic hypertension (CTEPH) and other types of pulmonary arterial hypertension. Why the synchrony between LV and RV is lost is unknown. We hypothesized that RV electrophysiological remodeling, notably, conduction slowing and action potential prolongation, contribute to this loss in synchrony. Methods and Results-We conducted epicardial mapping during pulmonary endarterectomy in 26 patients with CTEPH and compared these findings with clinical, hemodynamic, and echocardiographic variables. We consecutively placed a multielectrode grid on the epicardium of the RV free wall and LV lateral wall. These regions corresponded to RV and LV areas where echocardiographic Doppler sample volumes were placed to measure RV-to-LV diastolic interventricular delay. RV and LV epicardial action potential duration was assessed by measuring activation-recovery interval. Onset of diastolic relaxation of RV free wall with respect to LV lateral wall (diastolic interventricular delay) was delayed by 38 +/- 31 ms in patients with CTEPH versus -12 +/- 13 ms in control subjects (P <0.001), because, in patients with CTEPH, RV completed electric activation later than LV (65 +/- 20 versus 44 +/- 7 ms, P <0.001) and epicardial action potential duration, as assessed by activation-recovery interval measurement, was longer in RV free wall than in LV lateral wall (253 +/- 29 versus 240 +/- 22 ms, P <0.001). Conclusion-Additive effects of electrophysiological changes in RV, notably, conduction slowing and action potential prolongation, assessed by epicardial activation-recovery interval, contribute to diastolic interventricular delay in patients with CTEPH. (Circ Arrhythmia Electrophysiol. 2009; 2: 555-561.)
AB - Background-Delayed left ventricle (LV)-to-right ventricle (RV) peak shortening results in cardiac output reduction in patients with chronic thromboembolic hypertension (CTEPH) and other types of pulmonary arterial hypertension. Why the synchrony between LV and RV is lost is unknown. We hypothesized that RV electrophysiological remodeling, notably, conduction slowing and action potential prolongation, contribute to this loss in synchrony. Methods and Results-We conducted epicardial mapping during pulmonary endarterectomy in 26 patients with CTEPH and compared these findings with clinical, hemodynamic, and echocardiographic variables. We consecutively placed a multielectrode grid on the epicardium of the RV free wall and LV lateral wall. These regions corresponded to RV and LV areas where echocardiographic Doppler sample volumes were placed to measure RV-to-LV diastolic interventricular delay. RV and LV epicardial action potential duration was assessed by measuring activation-recovery interval. Onset of diastolic relaxation of RV free wall with respect to LV lateral wall (diastolic interventricular delay) was delayed by 38 +/- 31 ms in patients with CTEPH versus -12 +/- 13 ms in control subjects (P <0.001), because, in patients with CTEPH, RV completed electric activation later than LV (65 +/- 20 versus 44 +/- 7 ms, P <0.001) and epicardial action potential duration, as assessed by activation-recovery interval measurement, was longer in RV free wall than in LV lateral wall (253 +/- 29 versus 240 +/- 22 ms, P <0.001). Conclusion-Additive effects of electrophysiological changes in RV, notably, conduction slowing and action potential prolongation, assessed by epicardial activation-recovery interval, contribute to diastolic interventricular delay in patients with CTEPH. (Circ Arrhythmia Electrophysiol. 2009; 2: 555-561.)
U2 - https://doi.org/10.1161/CIRCEP.109.856021
DO - https://doi.org/10.1161/CIRCEP.109.856021
M3 - Article
C2 - 19843924
SN - 1941-3149
VL - 2
SP - 555-U107
JO - Circulation. Arrhythmia and electrophysiology
JF - Circulation. Arrhythmia and electrophysiology
IS - 5
ER -