Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis

Eveline Bruinstroop; Anne H. van der Spek; Anita Boelen

doi:https://doi.org/10.1530/ETJ-22-0211

Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis

Eveline Bruinstroop, Anne H. van der Spek, Anita Boelen

Research output: Contribution to journal › Review article › Academic › peer-review

5 Citations (Scopus)

Abstract

Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their inactive metabolites 3,3’,5’-tri-iodothyronine (rT3) and 3,3’-di-iodothyronine (3,3’-T2). Deiodinases are thus important for the regulation of intracellular thyroid hormone concentrations. This is known to be crucial both during development and adult life in regulating thyroid hormone-related gene transcription. This review discusses the importance of liver deiodinases in determining serum and liver thyroid hormone concentrations, liver metabolism and liver disease.

Original language	English
Article number	e220211
Journal	European thyroid journal
Volume	12
Issue number	3
DOIs	https://doi.org/10.1530/ETJ-22-0211
Publication status	Published - 1 Jun 2023

Keywords

NAFLD
deiodinases
hepatitis
liver
metabolism
thyroid

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https://doi.org/10.1530/ETJ-22-0211

Cite this

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title = "Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis",

abstract = "Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their inactive metabolites 3,3{\textquoteright},5{\textquoteright}-tri-iodothyronine (rT3) and 3,3{\textquoteright}-di-iodothyronine (3,3{\textquoteright}-T2). Deiodinases are thus important for the regulation of intracellular thyroid hormone concentrations. This is known to be crucial both during development and adult life in regulating thyroid hormone-related gene transcription. This review discusses the importance of liver deiodinases in determining serum and liver thyroid hormone concentrations, liver metabolism and liver disease.",

keywords = "NAFLD, deiodinases, hepatitis, liver, metabolism, thyroid",

author = "Eveline Bruinstroop and {van der Spek}, {Anne H.} and Anita Boelen",

note = "Funding Information: This study did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. Publisher Copyright: {\textcopyright} 2023 the author(s) Published by Bioscientifica Ltd.",

year = "2023",

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doi = "https://doi.org/10.1530/ETJ-22-0211",

language = "English",

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journal = "European thyroid journal",

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TY - JOUR

T1 - Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis

AU - Bruinstroop, Eveline

AU - van der Spek, Anne H.

AU - Boelen, Anita

N1 - Funding Information: This study did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. Publisher Copyright: © 2023 the author(s) Published by Bioscientifica Ltd.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their inactive metabolites 3,3’,5’-tri-iodothyronine (rT3) and 3,3’-di-iodothyronine (3,3’-T2). Deiodinases are thus important for the regulation of intracellular thyroid hormone concentrations. This is known to be crucial both during development and adult life in regulating thyroid hormone-related gene transcription. This review discusses the importance of liver deiodinases in determining serum and liver thyroid hormone concentrations, liver metabolism and liver disease.

AB - Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their inactive metabolites 3,3’,5’-tri-iodothyronine (rT3) and 3,3’-di-iodothyronine (3,3’-T2). Deiodinases are thus important for the regulation of intracellular thyroid hormone concentrations. This is known to be crucial both during development and adult life in regulating thyroid hormone-related gene transcription. This review discusses the importance of liver deiodinases in determining serum and liver thyroid hormone concentrations, liver metabolism and liver disease.

KW - NAFLD

KW - deiodinases

KW - hepatitis

KW - liver

KW - metabolism

KW - thyroid

UR - http://www.scopus.com/inward/record.url?scp=85161191087&partnerID=8YFLogxK

U2 - https://doi.org/10.1530/ETJ-22-0211

DO - https://doi.org/10.1530/ETJ-22-0211

M3 - Review article

C2 - 36892852

SN - 2235-0640

VL - 12

JO - European thyroid journal

JF - European thyroid journal

IS - 3

M1 - e220211

ER -

Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis

Abstract

Keywords

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