Abstract
Original language | English |
---|---|
Article number | 498 |
Journal | Nature communications |
Volume | 12 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 2021 |
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In: Nature communications, Vol. 12, No. 1, 498, 01.12.2021.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Sarcoma classification by DNA methylation profiling
AU - Koelsche, Christian
AU - Schrimpf, Daniel
AU - Stichel, Damian
AU - Sill, Martin
AU - Sahm, Felix
AU - Reuss, David E.
AU - Blattner, Mirjam
AU - Worst, Barbara
AU - Heilig, Christoph E.
AU - Beck, Katja
AU - Horak, Peter
AU - Kreutzfeldt, Simon
AU - Paff, Elke
AU - Stark, Sebastian
AU - Johann, Pascal
AU - Selt, Florian
AU - Ecker, Jonas
AU - Sturm, Dominik
AU - Pajtler, Kristian W.
AU - Reinhardt, Annekathrin
AU - Wefers, Annika K.
AU - Sievers, Philipp
AU - Ebrahimi, Azadeh
AU - Suwala, Abigail
AU - Fernández-Klett, Francisco
AU - Casalini, Belén
AU - Korshunov, Andrey
AU - Hovestadt, Volker
AU - Kommoss, Felix K. F.
AU - Kriegsmann, Mark
AU - Schick, Matthias
AU - Bewerunge-Hudler, Melanie
AU - Milde, Till
AU - Witt, Olaf
AU - Kulozik, Andreas E.
AU - Kool, Marcel
AU - Romero-Pérez, Laura
AU - Grünewald, Thomas G. P.
AU - Kirchner, Thomas
AU - Wick, Wolfgang
AU - Platten, Michael
AU - Unterberg, Andreas
AU - Uhl, Matthias
AU - Abdollahi, Amir
AU - Debus, J. rgen
AU - Lehner, Burkhard
AU - Thomas, Christian
AU - Hasselblatt, Martin
AU - Paulus, Werner
AU - Hartmann, Christian
AU - Staszewski, Ori
AU - Prinz, Marco
AU - Hench, J. rgen
AU - Frank, Stephan
AU - Versleijen-Jonkers, Yvonne M. H.
AU - Weidema, Marije E.
AU - Mentzel, Thomas
AU - Griewank, Klaus
AU - de Álava, Enrique
AU - Martín, Juan D. az
AU - Gastearena, Miguel A. Idoate
AU - Chang, Kenneth Tou-En
AU - Low, Sharon Yin Yee
AU - Cuevas-Bourdier, Adrian
AU - Mittelbronn, Michel
AU - Mynarek, Martin
AU - Rutkowski, Stefan
AU - Schüller, Ulrich
AU - Mautner, Viktor F.
AU - Schittenhelm, Jens
AU - Serrano, Jonathan
AU - Snuderl, Matija
AU - Büttner, Reinhard
AU - Klingebiel, Thomas
AU - Buslei, Rolf
AU - Gessler, Manfred
AU - Wesseling, Pieter
AU - Dinjens, Winand N. M.
AU - Brandner, Sebastian
AU - Jaunmuktane, Zane
AU - Lyskjær, Iben
AU - Schirmacher, Peter
AU - Stenzinger, Albrecht
AU - Brors, Benedikt
AU - Glimm, Hanno
AU - Heining, Christoph
AU - Tirado, Oscar M.
AU - Sáinz-Jaspeado, Miguel
AU - Mora, Jaume
AU - Alonso, Javier
AU - del Muro, Xavier Garcia
AU - Moran, Sebastian
AU - Esteller, Manel
AU - Benhamida, Jamal K.
AU - Ladanyi, Marc
AU - Wardelmann, Eva
AU - Antonescu, Cristina
AU - Flanagan, Adrienne
AU - Dirksen, Uta
AU - Hohenberger, Peter
AU - Baumhoer, Daniel
AU - Hartmann, Wolfgang
AU - Vokuhl, Christian
AU - Flucke, Uta
AU - Petersen, Iver
AU - Mechtersheimer, Gunhild
AU - Capper, David
AU - Jones, David T. W.
AU - Fröhling, Stefan
AU - Pfister, Stefan M.
AU - von Deimling, Andreas
N1 - Funding Information: This work was funded by Deutsche Krebshilfe grant 70112499, the NCT Heidelberg and an Illumina Medical Research Grant. Part of this work was funded by the National Institute of Health Research (to S.B. and Z.J.) and to UCLH Biomedical research centre (BRC399/NS/RB/101410). Human tissues were obtained from University College London NHS Foundation Trust as part of the UK Brain Archive Information Network (BRAIN UK, Ref: 18/004) which is funded by the Medical Research Council and Brain Tumour Research UK. The methylation profiling at NYU is supported by a grant from the Friedberg Charitable Foundation (to M.Sn.). M.Mi. would like to thank the Luxembourg National Research Fond (FNR) for the support (FNR PEARL P16/BM/ 11192868 grant). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.
AB - Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.
UR - http://www.scopus.com/inward/record.url?scp=85099975144&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41467-020-20603-4
DO - https://doi.org/10.1038/s41467-020-20603-4
M3 - Article
C2 - 33479225
SN - 2041-1723
VL - 12
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 498
ER -