Abstract
Original language | English |
---|---|
Article number | 18897 |
Journal | Scientific reports |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 2023 |
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In: Scientific reports, Vol. 13, No. 1, 18897, 01.12.2023.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks
AU - Helland, Ragnhild Holden
AU - Ferles, Alexandros
AU - Pedersen, André
AU - Kommers, Ivar
AU - Ardon, Hilko
AU - Barkhof, Frederik
AU - Bello, Lorenzo
AU - Berger, Mitchel S.
AU - Dunås, Tora
AU - Nibali, Marco Conti
AU - Furtner, Julia
AU - Hervey-Jumper, Shawn
AU - Idema, Albert J. S.
AU - Kiesel, Barbara
AU - Tewari, Rishi Nandoe
AU - Mandonnet, Emmanuel
AU - Müller, Domenique M. J.
AU - Robe, Pierre A.
AU - Rossi, Marco
AU - Sagberg, Lisa M.
AU - Sciortino, Tommaso
AU - Aalders, Tom
AU - Wagemakers, Michiel
AU - Widhalm, Georg
AU - Witte, Marnix G.
AU - Zwinderman, Aeilko H.
AU - Majewska, Paulina L.
AU - Jakola, Asgeir S.
AU - Solheim, Ole
AU - Hamer, Philip C. De Witt
AU - Reinertsen, Ingerid
AU - Eijgelaar, Roelant S.
AU - Bouget, David
N1 - Funding Information: Data were processed in digital labs at HUNT Cloud, Norwegian University of Science and Technology, Trondheim, Norway. FB is supported by the National Institute for Health Research (NIHR) biomedical research centre at UCLH. The PICTURE project is sponsored by an unrestricted grant of Stichting Hanarth fonds, “Machine learning for better neurosurgical decisions in patients with glioblastoma”; a grant for public-private partnerships (Amsterdam UMC PPP-grant) sponsored by the Dutch government (Ministry of Economic Affairs) through the Rijksdienst voor Ondernemend Nederland (RVO) and Topsector Life Sciences and Health (LSH), “Picturing predictions for patients with brain tumors”; a grant from the Innovative Medical Devices Initiative program, project number 10-10400-96-14003; The Netherlands Organisation for Scientific Research (NWO), 2020.027; a grant from the Dutch Cancer Society, VU2014-7113 and the Anita Veldman foundation, CCA2018-2-17. R.H.H. is supported by a grant from The Research Council of Norway, grant number 323339. D.B., I.R., and O.S. are partly funded by the Norwegian National Research Center for Minimally Invasive and Image-Guided Diagnostics and Therapy. Funding Information: Data were processed in digital labs at HUNT Cloud, Norwegian University of Science and Technology, Trondheim, Norway. FB is supported by the National Institute for Health Research (NIHR) biomedical research centre at UCLH. The PICTURE project is sponsored by an unrestricted grant of Stichting Hanarth fonds, “Machine learning for better neurosurgical decisions in patients with glioblastoma”; a grant for public-private partnerships (Amsterdam UMC PPP-grant) sponsored by the Dutch government (Ministry of Economic Affairs) through the Rijksdienst voor Ondernemend Nederland (RVO) and Topsector Life Sciences and Health (LSH), “Picturing predictions for patients with brain tumors”; a grant from the Innovative Medical Devices Initiative program, project number 10-10400-96-14003; The Netherlands Organisation for Scientific Research (NWO), 2020.027; a grant from the Dutch Cancer Society, VU2014-7113 and the Anita Veldman foundation, CCA2018-2-17. R.H.H. is supported by a grant from The Research Council of Norway, grant number 323339. D.B., I.R., and O.S. are partly funded by the Norwegian National Research Center for Minimally Invasive and Image-Guided Diagnostics and Therapy. Publisher Copyright: © 2023, The Author(s).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images is essential. The current standard method for estimating it is subject to high inter- and intra-rater variability, and an automated method for segmentation of residual tumor in early post-operative MRI could lead to a more accurate estimation of extent of resection. In this study, two state-of-the-art neural network architectures for pre-operative segmentation were trained for the task. The models were extensively validated on a multicenter dataset with nearly 1000 patients, from 12 hospitals in Europe and the United States. The best performance achieved was a 61% Dice score, and the best classification performance was about 80% balanced accuracy, with a demonstrated ability to generalize across hospitals. In addition, the segmentation performance of the best models was on par with human expert raters. The predicted segmentations can be used to accurately classify the patients into those with residual tumor, and those with gross total resection.
AB - Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images is essential. The current standard method for estimating it is subject to high inter- and intra-rater variability, and an automated method for segmentation of residual tumor in early post-operative MRI could lead to a more accurate estimation of extent of resection. In this study, two state-of-the-art neural network architectures for pre-operative segmentation were trained for the task. The models were extensively validated on a multicenter dataset with nearly 1000 patients, from 12 hospitals in Europe and the United States. The best performance achieved was a 61% Dice score, and the best classification performance was about 80% balanced accuracy, with a demonstrated ability to generalize across hospitals. In addition, the segmentation performance of the best models was on par with human expert raters. The predicted segmentations can be used to accurately classify the patients into those with residual tumor, and those with gross total resection.
UR - http://www.scopus.com/inward/record.url?scp=85175735540&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41598-023-45456-x
DO - https://doi.org/10.1038/s41598-023-45456-x
M3 - Article
C2 - 37919325
SN - 2045-2322
VL - 13
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 18897
ER -