@article{e60b3c50ccd244eaadc9a89385d0865c,
title = "Serum and cerebrospinal fluid Neutrophil gelatinase-associated lipocalin (NGAL) levels as biomarkers for the conversion from mild cognitive impairment to Alzheimer's disease dementia",
abstract = "Neutrophil gelatinase-associated lipocalin (NGAL) is an acute phase protein that has been reported as a potential marker for pre-dementia stages of Alzheimer's disease (AD). Longitudinal studies for its association with the conversion of mild cognitive impairment to AD is still lacking. This study included n = 268 study participants with subjective cognitive decline (SCD) (n=82), mild cognitive impairment (MCI) (n=98) and AD dementia (n=88) at baseline and two-year follow-up clinical assessments. Serum and cerebrospinal fluid (CSF)NGAL, CSF amyloid beta1-42, total-Tau, and phospho-Tau levels were measured with ELISA analysis. CSF NGAL levels were significantly lower in MCI participants compared to people with SCD at baseline. Lower baseline CSF NGAL levels predicted MCI converters to AD dementia vs. non-converters after 2-years follow-up. A positive correlation between CSF NGAL and amyloid beta1-42 was found particularly in MCI participants at baseline. NGAL in CSF holds potential to be used as a predictive marker for the conversion of MCI to AD dementia and may reflect pathophysiological processes of prodromal AD neuropathology.",
keywords = "Amyloid beta, Converters, Follow-up, Lipocalin 2, Neuroinflammation, Prodromal, Biomarker",
author = "Naud{\'e}, {Petrus J. W.} and Ramakers, {Inez H. G. B.} and {van der Flier}, {Wiesje M.} and Jiskoot, {Lize C.} and Reesink, {Fransje E.} and Claassen, {Jurgen A. H. R.} and Koek, {Huiberdina L.} and Eisel, {Ulrich L. M.} and {de Deyn}, {Peter P.}",
note = "Funding Information: This work was carried out in the context of Parelsnoer clinical biobanks at Health-RI ( https://www.health-ri.nl/initiatives/parelsnoer ). Before 2020, PSI was part of and funded by the Dutch Federation of University Medical Centers and has received initial funding from the Dutch Government (from 2007to 2011). This study was further funded by ZonMW Deltaplan Dementie Memorabel (733050815 and 733050501 to PJWN, PPDD and ULME), Alzheimer Research Center Groningen, IAP Network P7/16 funding of the Belgian Federal Science Policy Office, Methusalem excellence grant of the Flemish Government and University Research Fund of the University of Antwerp (to PPDD), NeuroSearch Antwerp (to PPDD and PJWN), Alzheimer Nederland (WE. 13-2015-19 to PJWN). Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = nov,
day = "1",
doi = "https://doi.org/10.1016/j.neurobiolaging.2021.07.001",
language = "English",
volume = "107",
pages = "1--10",
journal = "Neurobiology of aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
}