Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Benjamin J. Visser; Sophia G. de Vries; Rieke Vingerling; Martin Gritter; Danielle Kroon; Lídia Ciudad Aguilar; Rik B. J. Kraan; Rosanne W. Wieten; François Danion; Barbara Sjouke; Akim A. Adegnika; Selidji T. Agnandji; Peter G. Kremsner; Thomas Hänscheid; Petra F. Mens; Michèle van Vugt; Martin P. Grobusch

doi:https://doi.org/10.4269/ajtmh.16-0721

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Benjamin J. Visser, Sophia G. de Vries, Rieke Vingerling, Martin Gritter, Danielle Kroon, Lídia Ciudad Aguilar, Rik B. J. Kraan, Rosanne W. Wieten, François Danion, Barbara Sjouke, Akim A. Adegnika, Selidji T. Agnandji, Peter G. Kremsner, Thomas Hänscheid, Petra F. Mens, Michèle van Vugt, Martin P. Grobusch

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Abstract

AbstractThe serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol [TC] = 3.26 [standard deviation = 0.94] versus 3.97 [1.22; P < 0.001]; high-density lipoprotein cholesterol [HDL-C] = 0.43 [0.47] versus 1.05 [0.67; P < 0.001], low-density lipoprotein cholesterol [LDL-C] = 2.05 [0.76] versus 2.42 [0.90; P < 0.001]. Triglycerides (TGs) levels were higher in malaria patients (1.81 [1.02] versus 1.11 [0.82; P < 0.001]). No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 (TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology

Original language	English
Pages (from-to)	1205-1214
Journal	American journal of tropical medicine and hygiene
Volume	96
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.16-0721
Publication status	Published - 2017

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Cite this

Visser, B. J., de Vries, S. G., Vingerling, R., Gritter, M., Kroon, D., Aguilar, L. C., Kraan, R. B. J., Wieten, R. W., Danion, F., Sjouke, B., Adegnika, A. A., Agnandji, S. T., Kremsner, P. G., Hänscheid, T., Mens, P. F., van Vugt, M., & Grobusch, M. P. (2017). Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon. American journal of tropical medicine and hygiene, 96(5), 1205-1214. https://doi.org/10.4269/ajtmh.16-0721

@article{e85fabab285549c995ae86c19acebabb,

title = "Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambar{\'e}n{\'e}, Gabon",

abstract = "AbstractThe serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol [TC] = 3.26 [standard deviation = 0.94] versus 3.97 [1.22; P < 0.001]; high-density lipoprotein cholesterol [HDL-C] = 0.43 [0.47] versus 1.05 [0.67; P < 0.001], low-density lipoprotein cholesterol [LDL-C] = 2.05 [0.76] versus 2.42 [0.90; P < 0.001]. Triglycerides (TGs) levels were higher in malaria patients (1.81 [1.02] versus 1.11 [0.82; P < 0.001]). No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 (TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology",

author = "Visser, {Benjamin J.} and {de Vries}, {Sophia G.} and Rieke Vingerling and Martin Gritter and Danielle Kroon and Aguilar, {L{\'i}dia Ciudad} and Kraan, {Rik B. J.} and Wieten, {Rosanne W.} and Fran{\c c}ois Danion and Barbara Sjouke and Adegnika, {Akim A.} and Agnandji, {Selidji T.} and Kremsner, {Peter G.} and Thomas H{\"a}nscheid and Mens, {Petra F.} and {van Vugt}, Mich{\`e}le and Grobusch, {Martin P.}",

year = "2017",

doi = "https://doi.org/10.4269/ajtmh.16-0721",

language = "English",

volume = "96",

pages = "1205--1214",

journal = "American journal of tropical medicine and hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "5",

}

Visser, BJ, de Vries, SG, Vingerling, R, Gritter, M, Kroon, D, Aguilar, LC, Kraan, RBJ, Wieten, RW, Danion, F, Sjouke, B, Adegnika, AA, Agnandji, ST, Kremsner, PG, Hänscheid, T, Mens, PF , van Vugt, M & Grobusch, MP 2017, 'Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon', American journal of tropical medicine and hygiene, vol. 96, no. 5, pp. 1205-1214. https://doi.org/10.4269/ajtmh.16-0721

TY - JOUR

T1 - Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

AU - Visser, Benjamin J.

AU - de Vries, Sophia G.

AU - Vingerling, Rieke

AU - Gritter, Martin

AU - Kroon, Danielle

AU - Aguilar, Lídia Ciudad

AU - Kraan, Rik B. J.

AU - Wieten, Rosanne W.

AU - Danion, François

AU - Sjouke, Barbara

AU - Adegnika, Akim A.

AU - Agnandji, Selidji T.

AU - Kremsner, Peter G.

AU - Hänscheid, Thomas

AU - Mens, Petra F.

AU - van Vugt, Michèle

AU - Grobusch, Martin P.

PY - 2017

Y1 - 2017

N2 - AbstractThe serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol [TC] = 3.26 [standard deviation = 0.94] versus 3.97 [1.22; P < 0.001]; high-density lipoprotein cholesterol [HDL-C] = 0.43 [0.47] versus 1.05 [0.67; P < 0.001], low-density lipoprotein cholesterol [LDL-C] = 2.05 [0.76] versus 2.42 [0.90; P < 0.001]. Triglycerides (TGs) levels were higher in malaria patients (1.81 [1.02] versus 1.11 [0.82; P < 0.001]). No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 (TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology

AB - AbstractThe serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol [TC] = 3.26 [standard deviation = 0.94] versus 3.97 [1.22; P < 0.001]; high-density lipoprotein cholesterol [HDL-C] = 0.43 [0.47] versus 1.05 [0.67; P < 0.001], low-density lipoprotein cholesterol [LDL-C] = 2.05 [0.76] versus 2.42 [0.90; P < 0.001]. Triglycerides (TGs) levels were higher in malaria patients (1.81 [1.02] versus 1.11 [0.82; P < 0.001]). No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 (TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology

U2 - https://doi.org/10.4269/ajtmh.16-0721

DO - https://doi.org/10.4269/ajtmh.16-0721

M3 - Article

C2 - 28500816

SN - 0002-9637

VL - 96

SP - 1205

EP - 1214

JO - American journal of tropical medicine and hygiene

JF - American journal of tropical medicine and hygiene

IS - 5

ER -