Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

Alex F. De Vos; Debby A.J. Van Riel; Marjan Van Meurs; Herbert P.M. Brok; Louis Boon; Rogier Q. Hintzen; Eric Claassen; Bert A. 'T Hart; Jon D. Laman

doi:https://doi.org/10.1016/j.jneuroim.2004.12.002

Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

Alex F. De Vos, Debby A.J. Van Riel, Marjan Van Meurs, Herbert P.M. Brok, Louis Boon, Rogier Q. Hintzen, Eric Claassen, Bert A. 'T Hart, Jon D. Laman

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

Original language	English
Pages (from-to)	29-39
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	161
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.12.002
Publication status	Published - Apr 2005

Keywords

Acid Phosphatase
Animals
Antigens, CD
Autoimmunity
Callithrix
Comparative Study
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
Female
Humans
Immunoglobulin G
Immunoglobulin M
Immunohistochemistry
Journal Article
Lymphocyte Activation
Lymphocyte Depletion
Lymphocytes
Lymphoid organ
Lymphopenia
Macrophages
Male
Membrane Glycoproteins
Microscopy, Electron, Transmission
Multiple sclerosis
Myelin Sheath
Myelin oligodendrocyte glycoprotein
Non-human primate
Nuclear Proteins
Plasma Cells
Receptors, Immunologic
Sialic Acid Binding Ig-like Lectin 1
Spleen
T-Lymphocytes
ran GTP-Binding Protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1016/j.jneuroim.2004.12.002

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De Vos, A. F., Van Riel, D. A. J., Van Meurs, M., Brok, H. P. M., Boon, L., Hintzen, R. Q., Claassen, E., 'T Hart, B. A., & Laman, J. D. (2005). Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE). Journal of Neuroimmunology, 161(1-2), 29-39. https://doi.org/10.1016/j.jneuroim.2004.12.002

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title = "Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)",

abstract = "Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.",

keywords = "Acid Phosphatase, Animals, Antigens, CD, Autoimmunity, Callithrix, Comparative Study, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Female, Humans, Immunoglobulin G, Immunoglobulin M, Immunohistochemistry, Journal Article, Lymphocyte Activation, Lymphocyte Depletion, Lymphocytes, Lymphoid organ, Lymphopenia, Macrophages, Male, Membrane Glycoproteins, Microscopy, Electron, Transmission, Multiple sclerosis, Myelin Sheath, Myelin oligodendrocyte glycoprotein, Non-human primate, Nuclear Proteins, Plasma Cells, Receptors, Immunologic, Sialic Acid Binding Ig-like Lectin 1, Spleen, T-Lymphocytes, ran GTP-Binding Protein",

author = "{De Vos}, {Alex F.} and {Van Riel}, {Debby A.J.} and {Van Meurs}, Marjan and Brok, {Herbert P.M.} and Louis Boon and Hintzen, {Rogier Q.} and Eric Claassen and {'T Hart}, {Bert A.} and Laman, {Jon D.}",

year = "2005",

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doi = "https://doi.org/10.1016/j.jneuroim.2004.12.002",

language = "English",

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De Vos, AF, Van Riel, DAJ, Van Meurs, M, Brok, HPM, Boon, L, Hintzen, RQ, Claassen, E, 'T Hart, BA & Laman, JD 2005, 'Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)', Journal of Neuroimmunology, vol. 161, no. 1-2, pp. 29-39. https://doi.org/10.1016/j.jneuroim.2004.12.002

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AU - De Vos, Alex F.

AU - Van Riel, Debby A.J.

AU - Van Meurs, Marjan

AU - Brok, Herbert P.M.

AU - Boon, Louis

AU - Hintzen, Rogier Q.

AU - Claassen, Eric

AU - 'T Hart, Bert A.

AU - Laman, Jon D.

PY - 2005/4

Y1 - 2005/4

N2 - Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

AB - Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

KW - Acid Phosphatase

KW - Animals

KW - Antigens, CD

KW - Autoimmunity

KW - Callithrix

KW - Comparative Study

KW - Disease Models, Animal

KW - Encephalomyelitis, Autoimmune, Experimental

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Immunoglobulin M

KW - Immunohistochemistry

KW - Journal Article

KW - Lymphocyte Activation

KW - Lymphocyte Depletion

KW - Lymphocytes

KW - Lymphoid organ

KW - Lymphopenia

KW - Macrophages

KW - Male

KW - Membrane Glycoproteins

KW - Microscopy, Electron, Transmission

KW - Multiple sclerosis

KW - Myelin Sheath

KW - Myelin oligodendrocyte glycoprotein

KW - Non-human primate

KW - Nuclear Proteins

KW - Plasma Cells

KW - Receptors, Immunologic

KW - Sialic Acid Binding Ig-like Lectin 1

KW - Spleen

KW - T-Lymphocytes

KW - ran GTP-Binding Protein

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DO - https://doi.org/10.1016/j.jneuroim.2004.12.002

M3 - Article

C2 - 15748941

SN - 0165-5728

VL - 161

SP - 29

EP - 39

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

Abstract

Keywords

UN SDGs

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