TY - JOUR
T1 - Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice
AU - van Beers, Eduard J.
AU - van Tuijn, Charlotte F. J.
AU - Mac Gillavry, Melvin R.
AU - van der Giessen, Anna
AU - Schnog, John-John B.
AU - Biemond, Bart J.
PY - 2008
Y1 - 2008
N2 - In daily clinical practice, the frequency of painful crises (pain rate) is an important parameter of sickle cell disease severity. We assessed the prevalence of sickle cell disease-related organ damage and complications and their relation to pain rate. Organ damage and history of vaso-occlusive complications were obtained via systematic screening of consecutive patients and by chart review. In 104 adult sickle cell patients pain rate was related to a history of acute chest syndromes, avascular osteonecrosis, iron overload, priapism and cholelithiasis. However, major disease-related complications, such as microalbuminuria and pulmonary hypertension, were detected in 23% and 24% respectively of patients without painful crises in the study period underlining the importance of systematic screening for developing organ damage in sickle cell patients irrespective of pain rate
AB - In daily clinical practice, the frequency of painful crises (pain rate) is an important parameter of sickle cell disease severity. We assessed the prevalence of sickle cell disease-related organ damage and complications and their relation to pain rate. Organ damage and history of vaso-occlusive complications were obtained via systematic screening of consecutive patients and by chart review. In 104 adult sickle cell patients pain rate was related to a history of acute chest syndromes, avascular osteonecrosis, iron overload, priapism and cholelithiasis. However, major disease-related complications, such as microalbuminuria and pulmonary hypertension, were detected in 23% and 24% respectively of patients without painful crises in the study period underlining the importance of systematic screening for developing organ damage in sickle cell patients irrespective of pain rate
U2 - https://doi.org/10.3324/haematol.12152
DO - https://doi.org/10.3324/haematol.12152
M3 - Article
C2 - 18367483
SN - 0390-6078
VL - 93
SP - 757
EP - 760
JO - Haematologica
JF - Haematologica
IS - 5
ER -