TY - JOUR
T1 - State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis
AU - Haveman, Lizeth Y. F.
AU - Vugts, Danielle J.
AU - Windhorst, Albert D.
N1 - Publisher Copyright: © 2023, Springer Nature Switzerland AG.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Background: Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’ radiolabeling methodologies for the preparation of 18F-labeled tracers has appeared in order to improve the efficiency of the labeling reaction. Main body: Despite these developments, one outstanding challenge into the early key steps of the process remains: the preparation of reactive [18F]fluoride from oxygen-18 enriched water ([18O]H2O). In the last decade, significant changes into the trapping, elution and drying stages have been introduced. This review provides an overview of the strategies and recent developments in the production of reactive [18F]fluoride and its use for radiolabeling. Conclusion: Improved, modified or even completely new fluorine-18 work-up procedures have been developed in the last decade with widespread use in base-sensitive nucleophilic 18F-fluorination reactions. The many promising developments may lead to a few standardized drying methodologies for the routine production of a broad scale of PET tracers.
AB - Background: Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’ radiolabeling methodologies for the preparation of 18F-labeled tracers has appeared in order to improve the efficiency of the labeling reaction. Main body: Despite these developments, one outstanding challenge into the early key steps of the process remains: the preparation of reactive [18F]fluoride from oxygen-18 enriched water ([18O]H2O). In the last decade, significant changes into the trapping, elution and drying stages have been introduced. This review provides an overview of the strategies and recent developments in the production of reactive [18F]fluoride and its use for radiolabeling. Conclusion: Improved, modified or even completely new fluorine-18 work-up procedures have been developed in the last decade with widespread use in base-sensitive nucleophilic 18F-fluorination reactions. The many promising developments may lead to a few standardized drying methodologies for the routine production of a broad scale of PET tracers.
KW - Fluorine-18
KW - Radiopharmaceutical chemistry
UR - http://www.scopus.com/inward/record.url?scp=85174174274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85174174274&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s41181-023-00203-5
DO - https://doi.org/10.1186/s41181-023-00203-5
M3 - Review article
C2 - 37824021
SN - 2365-421X
VL - 8
SP - 1
EP - 31
JO - EJNMMI radiopharmacy and chemistry
JF - EJNMMI radiopharmacy and chemistry
IS - 1
M1 - 28
ER -