TY - JOUR
T1 - Subdural hematoma in an infant with alpha-1-antitrypsin deficiency and a rare primary intra-osseous vascular malformation
AU - Vester, M. E. M.
AU - van Rijn, R. R.
AU - Bem, R. A.
AU - Maes, A.
AU - Kubat, B.
PY - 2018
Y1 - 2018
N2 - We present a unique case of a four-week-old boy who died of a severe hypoxic encephalopathy due to a subdural hematoma. A week before his demise, a small left sided parieto-occipital subdural hemorrhage was seen on both CT and MRI. On the right side a larger, fronto-parietal subdural hemorrhage was present with a prominently defined protuberance to the right hemisphere, causing a midline shift to the left. Subdural hematomas have a broad differential diagnosis, including abusive head trauma which can have far reaching consequences. In order to diagnose the underlying cause of the subdural hematoma, and subsequently confirm or refute the differential diagnosis, a medicolegal autopsy was ordered. The autopsy revealed a rare primary intraosseous vascular malformation of the skull, at the location of the subdural hematoma. This, in combination with the coagulation disorder due to alpha-1-antitrypsin deficiency, was considered to be the underlying cause of death.
AB - We present a unique case of a four-week-old boy who died of a severe hypoxic encephalopathy due to a subdural hematoma. A week before his demise, a small left sided parieto-occipital subdural hemorrhage was seen on both CT and MRI. On the right side a larger, fronto-parietal subdural hemorrhage was present with a prominently defined protuberance to the right hemisphere, causing a midline shift to the left. Subdural hematomas have a broad differential diagnosis, including abusive head trauma which can have far reaching consequences. In order to diagnose the underlying cause of the subdural hematoma, and subsequently confirm or refute the differential diagnosis, a medicolegal autopsy was ordered. The autopsy revealed a rare primary intraosseous vascular malformation of the skull, at the location of the subdural hematoma. This, in combination with the coagulation disorder due to alpha-1-antitrypsin deficiency, was considered to be the underlying cause of death.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046770588&origin=inward
U2 - https://doi.org/10.1016/j.jofri.2018.05.001
DO - https://doi.org/10.1016/j.jofri.2018.05.001
M3 - Article
SN - 2212-4780
VL - 13
SP - 23
EP - 26
JO - Journal of Forensic Radiology and Imaging
JF - Journal of Forensic Radiology and Imaging
ER -