Suicidal ideation and suicide attempts: associations with sleep duration, insomnia, and inflammation

Michael R Dolsen, Aric A Prather, Femke Lamers, Brenda W J H Penninx

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28 Citations (Scopus)


Background Sleep disturbance has been consistently identified as an independent contributor to suicide risk. Inflammation has emerged as a potential mechanism linked to both sleep disturbance and suicide risk. This study tested associations between sleep duration, insomnia, and inflammation on suicidal ideation (SI) and history of a suicide attempt (SA). Methods Participants included 2329 adults with current or remitted depression and/or anxiety enrolled in the Netherlands Study of Depression and Anxiety. Sleep duration, insomnia, past week SI, and SA were assessed with self-report measures. Plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α were obtained. Results Short sleep duration (

Original languageEnglish
Pages (from-to)2094-2103
Number of pages10
JournalPsychological Medicine
Issue number12
Early online date23 Apr 2020
Publication statusPublished - Sept 2021


  • Anxiety
  • depression
  • inflammation
  • insomnia
  • sleep
  • suicide

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