Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation

B. Janssen; D.J. Vugts; U. Funke; A. Spaans; R.C. Schuit; E. Kooijman; M. Rongen; L.R. Perk; A.A. Lammertsma; A.D. Windhorst

doi:https://doi.org/10.1002/jlcr.3206

Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation

B. Janssen, D.J. Vugts, U. Funke, A. Spaans, R.C. Schuit, E. Kooijman, M. Rongen, L.R. Perk, A.A. Lammertsma, A.D. Windhorst

Radiology and Nuclear Medicine (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

67 Citations (Scopus)

Abstract

Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X

Original language	English
Pages (from-to)	509-516
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	57
Issue number	8
DOIs	https://doi.org/10.1002/jlcr.3206
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1002/jlcr.3206

Cite this

Janssen, B., Vugts, D. J., Funke, U., Spaans, A., Schuit, R. C., Kooijman, E., Rongen, M., Perk, L. R., Lammertsma, A. A., & Windhorst, A. D. (2014). Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation. Journal of Labelled Compounds and Radiopharmaceuticals, 57(8), 509-516. https://doi.org/10.1002/jlcr.3206

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Janssen, B , Vugts, DJ, Funke, U, Spaans, A, Schuit, RC, Kooijman, E, Rongen, M, Perk, LR, Lammertsma, AA & Windhorst, AD 2014, 'Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 57, no. 8, pp. 509-516. https://doi.org/10.1002/jlcr.3206

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AU - Spaans, A.

AU - Schuit, R.C.

AU - Kooijman, E.

AU - Rongen, M.

AU - Perk, L.R.

AU - Lammertsma, A.A.

AU - Windhorst, A.D.

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