Abstract
Gene therapy is one of the promising strategies in cancer treatment. Recent studies identified molecular targets on angiogenically activated endothelial cells that can be used to deliver gene-transfer vehicles to the tumor site specifically. Furthermore, non-viral vehicles are emerging as an alternative for traditional viral gene-therapy approaches. Here, we describe how viral and non-viral gene-transfer vehicles have been and can be modified to target tumor endothelial cells for anti-angiogenesis gene therapy. Improving the specificity and safety of existing gene-therapy vehicles will make angiogenesis-targeted cancer gene therapy a valuable tool in the clinical setting.
Original language | English |
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Pages (from-to) | 200-9 |
Number of pages | 10 |
Journal | Trends in molecular medicine |
Volume | 13 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2007 |
Keywords
- Animals
- Drug Carriers/therapeutic use
- Gene Targeting/methods
- Genetic Therapy/methods
- Genetic Vectors/therapeutic use
- Humans
- Models, Biological
- Neoplasms/blood supply
- Neovascularization, Pathologic/therapy
- Viruses/genetics