The association between metabolic syndrome, obesity-related outcomes, and ADHD in adults with comorbid affective disorders

Dora Wynchank, Denise Bijlenga, Femke Lamers, J. J.Sandra Kooij, Tannetje I. Bron, Aartjan T.F. Beekman, Brenda W.J.H. Penninx

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Objective: ADHD may predispose to obesity, a metabolic syndrome component. Affective disorders are also associated with MetSyn and ADHD. This study examined whether ADHD confers any added risk of MetSyn and obesity-related associations in a large sample with varying stages of affective disorders. Method: Participants included 2,303 adults from the Netherlands Study of Depression and Anxiety. Three groups were compared (controls, those with depressive/anxiety disorders without ADHD; and those with depressive/anxiety disorders and ADHD) for presence of MetSyn risk factors, body mass index, and waist–hip ratio. ADHD symptoms were identified by using a T-score > 65 (Conners Adult ADHD Rating Scale). Results: Multivariable analyses were additionally adjusted for sociodemographic, lifestyle, health factors, and affective disorders. Analyses showed no significant association between MetSyn, obesity-related variables, and comorbid ADHD. High Inattention and Hyperactivity/Impulsivity symptoms were not associated with MetSyn. Conclusion: This study did not confirm that MetSyn and obesity-related parameters are increased in comorbid ADHD.

Original languageEnglish
Pages (from-to)460-471
Number of pages12
JournalJournal of Attention Disorders
Issue number5
Publication statusPublished - 1 Mar 2018


  • ADHD
  • anxiety
  • depression
  • metabolic syndrome

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