The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells

Wouter Smit; Jarom Heijmans

doi:https://doi.org/10.1080/23723556.2021.1879614

The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells

Research output: Contribution to journal › Comment/Letter to the editor › Academic

Abstract

Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor–receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD4, and TP53 are enhancers of the global mRNA translational capacity, which is linked to intestinal cell growth in an mTOR-dependent manner.

Original language	English
Article number	1879614
Journal	Molecular & cellular oncology
Volume	8
Issue number	4
Early online date	2021
DOIs	https://doi.org/10.1080/23723556.2021.1879614
Publication status	Published - 2021

Keywords

Colorectal cancer
driver mutations
global translation
mTOR signaling
protein synthesis

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https://doi.org/10.1080/23723556.2021.1879614

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title = "The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells",

abstract = "Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor–receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD4, and TP53 are enhancers of the global mRNA translational capacity, which is linked to intestinal cell growth in an mTOR-dependent manner.",

keywords = "Colorectal cancer, driver mutations, global translation, mTOR signaling, protein synthesis",

author = "Wouter Smit and Jarom Heijmans",

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AU - Smit, Wouter

AU - Heijmans, Jarom

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AB - Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor–receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD4, and TP53 are enhancers of the global mRNA translational capacity, which is linked to intestinal cell growth in an mTOR-dependent manner.

KW - Colorectal cancer

KW - driver mutations

KW - global translation

KW - mTOR signaling

KW - protein synthesis

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DO - https://doi.org/10.1080/23723556.2021.1879614

M3 - Comment/Letter to the editor

C2 - 34616863

SN - 2372-3548

VL - 8

JO - Molecular & cellular oncology

JF - Molecular & cellular oncology

IS - 4

M1 - 1879614

ER -

The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells

Abstract

Keywords

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