TY - JOUR
T1 - The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users
AU - Schulte, Mieke H. J.
AU - Kaag, Anne Marije
AU - Boendermaker, Wouter J.
AU - Brink, Wim van den
AU - Goudriaan, Anna E.
AU - Wiers, Reinout W.
N1 - With supplementary file.
PY - 2019/5/30
Y1 - 2019/5/30
N2 - The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.
AB - The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.
KW - Acetylcysteine/pharmacology
KW - Brain/drug effects
KW - Cocaine-Related Disorders/physiopathology
KW - Cocaine/adverse effects
KW - Cognition
KW - Cues
KW - Double-Blind Method
KW - Functional magnetic resonance imaging
KW - Humans
KW - Interventions
KW - Male
KW - Memory, Short-Term
KW - Substance use disorders
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064176541&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30991248
UR - http://www.scopus.com/inward/record.url?scp=85064176541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064176541&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/39729142/1_s2.0_S0925492719300836_mmc2.docx
U2 - https://doi.org/10.1016/j.pscychresns.2019.03.011
DO - https://doi.org/10.1016/j.pscychresns.2019.03.011
M3 - Article
C2 - 30991248
SN - 0925-4927
VL - 287
SP - 56
EP - 59
JO - PSYCHIATRY RESEARCH-NEUROIMAGING
JF - PSYCHIATRY RESEARCH-NEUROIMAGING
ER -
