TY - JOUR
T1 - The effect of timing of an immediate instillation of mitomycin C after transurethral resection in 941 patients with non-muscle-invasive bladder cancer
AU - Bosschieter, Judith
AU - van Moorselaar, R. Jeroen A.
AU - Vis, André N.
AU - van Ginkel, Tessa
AU - Lissenberg-Witte, Birgit I.
AU - Beckers, Goedele M. A.
AU - Nieuwenhuijzen, Jakko A.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Objective: To investigate whether the timing of an immediate instillation of mitomycin C (on the day of transurethral resection of bladder tumour [TURBT] or 1 day later) has an impact on time to recurrence of non-muscle-invasive bladder cancer (NMIBC). Patients and Methods: All patients with NMIBC who were enrolled in a prospective trial between 1998 and 2003, and treated with an early mitomycin C instillation (on the day of TURBT or 1 day later), were selected. Statistical analysis was performed with Kaplan–Meier curves and multivariable Cox regression. Results: Administering an instillation of mitomycin C on the day of TURBT or 1 day later did not show a statistically significant difference in time to recurrence in a univariable model (log-rank P = 0.99). After correcting for the number of scheduled adjuvant instillations, no statistically significant difference could be detected either: hazard ratio 1.05 (95% confidence interval 0.81–1.35, P = 0.74). Conclusion: These data do not support the hypothesis that a very early instillation (on the day of TURBT) of mitomycin C decreases the risk of recurrence as compared with an early instillation (1 day after TURBT).
AB - Objective: To investigate whether the timing of an immediate instillation of mitomycin C (on the day of transurethral resection of bladder tumour [TURBT] or 1 day later) has an impact on time to recurrence of non-muscle-invasive bladder cancer (NMIBC). Patients and Methods: All patients with NMIBC who were enrolled in a prospective trial between 1998 and 2003, and treated with an early mitomycin C instillation (on the day of TURBT or 1 day later), were selected. Statistical analysis was performed with Kaplan–Meier curves and multivariable Cox regression. Results: Administering an instillation of mitomycin C on the day of TURBT or 1 day later did not show a statistically significant difference in time to recurrence in a univariable model (log-rank P = 0.99). After correcting for the number of scheduled adjuvant instillations, no statistically significant difference could be detected either: hazard ratio 1.05 (95% confidence interval 0.81–1.35, P = 0.74). Conclusion: These data do not support the hypothesis that a very early instillation (on the day of TURBT) of mitomycin C decreases the risk of recurrence as compared with an early instillation (1 day after TURBT).
KW - Intravesical chemotherapy
KW - Mitomycin C
KW - Urinary bladder neoplasms
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041216029&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29319922
UR - http://www.scopus.com/inward/record.url?scp=85041216029&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/bju.14124
DO - https://doi.org/10.1111/bju.14124
M3 - Article
C2 - 29319922
SN - 1464-4096
VL - 122
SP - 571
EP - 575
JO - BJU international
JF - BJU international
IS - 4
ER -