TY - JOUR
T1 - The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study
AU - Bosma, I.
AU - Stam, C.J.
AU - Douw, L.
AU - Bartolomei, F.
AU - Heimans, J.J.
AU - van Dijk, B.W.
AU - Postma, T.J.
AU - Klein, M.
AU - Reijneveld, J.C.
PY - 2008
Y1 - 2008
N2 - Purpose: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction. Patient and methods: Resting state MEG recordings were obtained from 17LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered. Results: LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory. Conclusion: LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits. © The Author(s) 2008.
AB - Purpose: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction. Patient and methods: Resting state MEG recordings were obtained from 17LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered. Results: LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory. Conclusion: LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits. © The Author(s) 2008.
U2 - https://doi.org/10.1007/s11060-008-9535-3
DO - https://doi.org/10.1007/s11060-008-9535-3
M3 - Article
C2 - 18259691
SN - 0167-594X
VL - 88
SP - 77
EP - 85
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 1
ER -