TY - JOUR
T1 - The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men
AU - la Fleur, Susanne E.
AU - Serlie, Mireille J.
PY - 2014
Y1 - 2014
N2 - Aberrant feeding behavior can lead to obesity and obesity-related medical consequences, such as insulin resistance and diabetes. Although alterations in glucose metabolism (i.e. insulin resistance), in the presence of excessive fat tissue are often explained by the consequences of dysfunctional adipose tissue, evidence is emerging that also altered brain functions might be an important determinant of insulin resistance. In this review, we provide an overview of how feeding behavior and obesity interact with brain circuitry and how these interactions affect glucose metabolism. Because brain circuitries involved in food intake have been shown to partly control glucose metabolism as well, targeting these circuitries in obese subjects might not only affect food intake and body weight but also glucose metabolism
AB - Aberrant feeding behavior can lead to obesity and obesity-related medical consequences, such as insulin resistance and diabetes. Although alterations in glucose metabolism (i.e. insulin resistance), in the presence of excessive fat tissue are often explained by the consequences of dysfunctional adipose tissue, evidence is emerging that also altered brain functions might be an important determinant of insulin resistance. In this review, we provide an overview of how feeding behavior and obesity interact with brain circuitry and how these interactions affect glucose metabolism. Because brain circuitries involved in food intake have been shown to partly control glucose metabolism as well, targeting these circuitries in obese subjects might not only affect food intake and body weight but also glucose metabolism
U2 - https://doi.org/10.1016/j.beem.2014.06.001
DO - https://doi.org/10.1016/j.beem.2014.06.001
M3 - Article
C2 - 25256761
SN - 1521-690X
VL - 28
SP - 649
EP - 659
JO - Best practice & research. Clinical endocrinology & metabolism
JF - Best practice & research. Clinical endocrinology & metabolism
IS - 5
ER -