The Netherlands study of depression in older persons (NESDO); a prospective cohort study

H.C. Comijs; H.W.J. van Marwijk; R.C. van der Mast; P. Naarding; R. Oude Voshaar; A.T.F. Beekman; M. Boshuisen; J. Dekker; R. Kok; M.W.M. de Waal; B.W.J.H. Penninx; M.L. Stek; J.H. Smit

doi:https://doi.org/10.1186/1756-0500-4-524

The Netherlands study of depression in older persons (NESDO); a prospective cohort study

H.C. Comijs, H.W.J. van Marwijk, R.C. van der Mast, P. Naarding, R. Oude Voshaar, A.T.F. Beekman, M. Boshuisen, J. Dekker, R. Kok, M.W.M. de Waal, B.W.J.H. Penninx, M.L. Stek, J.H. Smit

Research output: Contribution to journal › Article › Academic › peer-review

140 Citations (Scopus)

Abstract

Background: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. Methods. We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. Results: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons ( 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. Conclusions: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons. © 2011 Comijs et al; licensee BioMed Central Ltd.

Original language	English
Article number	524
Journal	BMC Research Notes
Volume	4
DOIs	https://doi.org/10.1186/1756-0500-4-524
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1186/1756-0500-4-524

Cite this

Comijs, H. C., van Marwijk, H. W. J., van der Mast, R. C., Naarding, P., Oude Voshaar, R., Beekman, A. T. F., Boshuisen, M., Dekker, J., Kok, R., de Waal, M. W. M., Penninx, B. W. J. H., Stek, M. L., & Smit, J. H. (2011). The Netherlands study of depression in older persons (NESDO); a prospective cohort study. BMC Research Notes, 4, Article 524. https://doi.org/10.1186/1756-0500-4-524

@article{9f33a96b07da47308bd40290298a23dd,

title = "The Netherlands study of depression in older persons (NESDO); a prospective cohort study",

abstract = "Background: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. Methods. We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. Results: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons ( 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. Conclusions: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons. {\textcopyright} 2011 Comijs et al; licensee BioMed Central Ltd.",

author = "H.C. Comijs and {van Marwijk}, H.W.J. and {van der Mast}, R.C. and P. Naarding and {Oude Voshaar}, R. and A.T.F. Beekman and M. Boshuisen and J. Dekker and R. Kok and {de Waal}, M.W.M. and B.W.J.H. Penninx and M.L. Stek and J.H. Smit",

year = "2011",

doi = "https://doi.org/10.1186/1756-0500-4-524",

language = "English",

volume = "4",

journal = "BMC Research Notes",

issn = "1756-0500",

publisher = "BioMed Central",

}

TY - JOUR

T1 - The Netherlands study of depression in older persons (NESDO); a prospective cohort study

AU - Comijs, H.C.

AU - van Marwijk, H.W.J.

AU - van der Mast, R.C.

AU - Naarding, P.

AU - Oude Voshaar, R.

AU - Beekman, A.T.F.

AU - Boshuisen, M.

AU - Dekker, J.

AU - Kok, R.

AU - de Waal, M.W.M.

AU - Penninx, B.W.J.H.

AU - Stek, M.L.

AU - Smit, J.H.

PY - 2011

Y1 - 2011

N2 - Background: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. Methods. We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. Results: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons ( 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. Conclusions: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons. © 2011 Comijs et al; licensee BioMed Central Ltd.

AB - Background: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. Methods. We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. Results: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons ( 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. Conclusions: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons. © 2011 Comijs et al; licensee BioMed Central Ltd.

U2 - https://doi.org/10.1186/1756-0500-4-524

DO - https://doi.org/10.1186/1756-0500-4-524

M3 - Article

C2 - 22142532

SN - 1756-0500

VL - 4

JO - BMC Research Notes

JF - BMC Research Notes

M1 - 524

ER -