The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

Daniele Campa; Manuel Gentiluomo; Angelika Stein; Mateus N. brega Aoki; Martin Oliverius; Ludmila Vodičková; Krzysztof Jamroziak; George Theodoropoulos; Claudio Pasquali; William Greenhalf; Paolo Giorgio Arcidiacono; Faik Uzunoglu; Raffaele Pezzilli; Claudio Luchini; Marta Puzzono; Martin Loos; Matteo Giaccherini; Verena Katzke; Andrea Mambrini; Edita Kiudeliene; Kauffmann Emanuele Federico; Julia Johansen; Tamás Hussein; Beatrice Mohelnikova-Duchonova; Casper H. J. van Eijck; Hermann Brenner; Riccardo Farinella; Juan Sainz Pérez; Martin Lovecek; Markus W. Büchler; Viktor Hlavac; Jakob R. Izbicki; Thilo Hackert; Roger Chammas; Alessandro Zerbi; Rita Lawlor; Alessio Felici; Mara Götz; Gabriele Capurso; Laura Ginocchi; Maria Gazouli; Juozas Kupcinskas; Giulia Martina Cavestro; Pavel Vodicka; Stefania Moz; John P. Neoptolemos; Lumir Kunovsky; Stig E. Bojesen; Silvia Carrara; Domenica Gioffreda; Egidijus Morkunas; Olga Abian; Stefania Bunduc; Daniela Basso; Ugo Boggi; Barbara Wlodarczyk; Andrea Szentesi; Giuseppe Vanella; Inna Chen; Maarten F. Bijlsma; Vytautas Kiudelis; Stefano Landi; Ben Schöttker; Chiara Corradi; Nathalia Giese; Rudolf Kaaks; Giulia Peduzzi; P. ter Hegyi; Luca Morelli; Niccolò Furbetta; Pavel Soucek; Anna Latiano; Renata Talar-Wojnarowska; Sidsel C. Lindgaard; Frederike Dijk; Anna Caterina Milanetto; Francesca Tavano; Klara Cervena; B. lint Erőss; Sabrina G. Testoni; Judith H. E. Verhagen-Oldenampsen; Ewa Małecka-Wojciesko; Eithne Costello; Roberto Salvia; Evaristo Maiello; Stefano Ermini; Cosimo Sperti; Bernd Holleczek; Francesco Perri; Jurgita Skieceviciene; Livia Archibugi; Maurizio Lucchesi; Cosmeri Rizzato; Federico Canzian

doi:https://doi.org/10.1016/j.critrevonc.2023.104020

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus N. brega Aoki, Martin Oliverius, Ludmila Vodičková, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita KiudelieneKauffmann Emanuele Federico, Julia Johansen, Tamás Hussein, Beatrice Mohelnikova-Duchonova, Casper H. J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Pérez, Martin Lovecek, Markus W. Büchler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Götz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schöttker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, P. ter Hegyi, Luca Morelli, Niccolò Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederike Dijk, Anna Caterina Milanetto, Francesca Tavano, Klara Cervena, B. lint Erőss, Sabrina G. Testoni, Judith H. E. Verhagen-Oldenampsen, Ewa Małecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian

Research output: Contribution to journal › Review article › Academic › peer-review

6 Citations (Scopus)

Abstract

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

Original language	English
Article number	104020
Journal	Critical Reviews in Oncology/Hematology
Volume	186
DOIs	https://doi.org/10.1016/j.critrevonc.2023.104020
Publication status	Published - 1 Jun 2023

Keywords

Chronic pancreatitis
Consortium
Genetic epidemiology
Intraductal papillary mucinous neoplasms
Pancreatic cancer
Pancreatic ductal adenocarcinoma
Pancreatic neuroendocrine tumors

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https://doi.org/10.1016/j.critrevonc.2023.104020

Cite this

Campa, D., Gentiluomo, M., Stein, A., Aoki, M. N. B., Oliverius, M., Vodičková, L., Jamroziak, K., Theodoropoulos, G., Pasquali, C., Greenhalf, W., Arcidiacono, P. G., Uzunoglu, F., Pezzilli, R., Luchini, C., Puzzono, M., Loos, M., Giaccherini, M., Katzke, V., Mambrini, A., ... Canzian, F. (2023). The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. Critical Reviews in Oncology/Hematology, 186, Article 104020. https://doi.org/10.1016/j.critrevonc.2023.104020

@article{900f88eed9604483be61f53bb3016c4e,

title = "The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years{\textquoteright} experience of association studies to understand the genetic architecture of pancreatic cancer",

abstract = "Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.",

keywords = "Chronic pancreatitis, Consortium, Genetic epidemiology, Intraductal papillary mucinous neoplasms, Pancreatic cancer, Pancreatic ductal adenocarcinoma, Pancreatic neuroendocrine tumors",

author = "Daniele Campa and Manuel Gentiluomo and Angelika Stein and Aoki, {Mateus N. brega} and Martin Oliverius and Ludmila Vodi{\v c}kov{\'a} and Krzysztof Jamroziak and George Theodoropoulos and Claudio Pasquali and William Greenhalf and Arcidiacono, {Paolo Giorgio} and Faik Uzunoglu and Raffaele Pezzilli and Claudio Luchini and Marta Puzzono and Martin Loos and Matteo Giaccherini and Verena Katzke and Andrea Mambrini and Edita Kiudeliene and Federico, {Kauffmann Emanuele} and Julia Johansen and Tam{\'a}s Hussein and Beatrice Mohelnikova-Duchonova and {van Eijck}, {Casper H. J.} and Hermann Brenner and Riccardo Farinella and P{\'e}rez, {Juan Sainz} and Martin Lovecek and B{\"u}chler, {Markus W.} and Viktor Hlavac and Izbicki, {Jakob R.} and Thilo Hackert and Roger Chammas and Alessandro Zerbi and Rita Lawlor and Alessio Felici and Mara G{\"o}tz and Gabriele Capurso and Laura Ginocchi and Maria Gazouli and Juozas Kupcinskas and Cavestro, {Giulia Martina} and Pavel Vodicka and Stefania Moz and Neoptolemos, {John P.} and Lumir Kunovsky and Bojesen, {Stig E.} and Silvia Carrara and Domenica Gioffreda and Egidijus Morkunas and Olga Abian and Stefania Bunduc and Daniela Basso and Ugo Boggi and Barbara Wlodarczyk and Andrea Szentesi and Giuseppe Vanella and Inna Chen and Bijlsma, {Maarten F.} and Vytautas Kiudelis and Stefano Landi and Ben Sch{\"o}ttker and Chiara Corradi and Nathalia Giese and Rudolf Kaaks and Giulia Peduzzi and Hegyi, {P. ter} and Luca Morelli and Niccol{\`o} Furbetta and Pavel Soucek and Anna Latiano and Renata Talar-Wojnarowska and Lindgaard, {Sidsel C.} and Frederike Dijk and Milanetto, {Anna Caterina} and Francesca Tavano and Klara Cervena and Er{\H o}ss, {B. lint} and Testoni, {Sabrina G.} and Verhagen-Oldenampsen, {Judith H. E.} and Ewa Ma{\l}ecka-Wojciesko and Eithne Costello and Roberto Salvia and Evaristo Maiello and Stefano Ermini and Cosimo Sperti and Bernd Holleczek and Francesco Perri and Jurgita Skieceviciene and Livia Archibugi and Maurizio Lucchesi and Cosmeri Rizzato and Federico Canzian",

note = "Funding Information: The research leading to these results has received funding from Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019—ID. 23672 project—P.I. Campa Daniele and IG 2021 ID – 26201 project P.I. Gabriele Capurso. PV, LV and KC acknowledge the support from the AZV , The Czech Ministry of Health , NU21–07–00247 and from Programme EXCELES , ID Project No. LX22NPO5102 . Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), Italy has received funding by the Italian Minister of Health , Ricerca Corrente program 2022–2024 , and by the and by the “5 × 1000″ voluntary contribution. Costello, E and Greenhalf, W are supported by grants from, Cancer Research UK ( C7690/A26881 , C18616/A25153 ) and Pancreatic Cancer UK . Sample accrual at the Amsterdam UMC was supported by the AMC Foundation . This article is based upon work from COST Action TRANSPAN, CA21116 , supported by COST (European Cooperation in Science and Technology). Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = jun,

day = "1",

doi = "https://doi.org/10.1016/j.critrevonc.2023.104020",

language = "English",

volume = "186",

journal = "Critical Reviews in Oncology/Hematology",

issn = "1040-8428",

publisher = "Elsevier Ireland Ltd",

}

Campa, D, Gentiluomo, M, Stein, A, Aoki, MNB, Oliverius, M, Vodičková, L, Jamroziak, K, Theodoropoulos, G, Pasquali, C, Greenhalf, W, Arcidiacono, PG, Uzunoglu, F, Pezzilli, R, Luchini, C, Puzzono, M, Loos, M, Giaccherini, M, Katzke, V, Mambrini, A, Kiudeliene, E, Federico, KE, Johansen, J, Hussein, T, Mohelnikova-Duchonova, B, van Eijck, CHJ, Brenner, H, Farinella, R, Pérez, JS, Lovecek, M, Büchler, MW, Hlavac, V, Izbicki, JR, Hackert, T, Chammas, R, Zerbi, A, Lawlor, R, Felici, A, Götz, M, Capurso, G, Ginocchi, L, Gazouli, M, Kupcinskas, J, Cavestro, GM, Vodicka, P, Moz, S, Neoptolemos, JP, Kunovsky, L, Bojesen, SE, Carrara, S, Gioffreda, D, Morkunas, E, Abian, O, Bunduc, S, Basso, D, Boggi, U, Wlodarczyk, B, Szentesi, A, Vanella, G, Chen, I, Bijlsma, MF, Kiudelis, V, Landi, S, Schöttker, B, Corradi, C, Giese, N, Kaaks, R, Peduzzi, G, Hegyi, PT, Morelli, L, Furbetta, N, Soucek, P, Latiano, A, Talar-Wojnarowska, R, Lindgaard, SC, Dijk, F, Milanetto, AC, Tavano, F, Cervena, K, Erőss, BL, Testoni, SG, Verhagen-Oldenampsen, JHE, Małecka-Wojciesko, E, Costello, E, Salvia, R, Maiello, E, Ermini, S, Sperti, C, Holleczek, B, Perri, F, Skieceviciene, J, Archibugi, L, Lucchesi, M, Rizzato, C & Canzian, F 2023, 'The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer', Critical Reviews in Oncology/Hematology, vol. 186, 104020. https://doi.org/10.1016/j.critrevonc.2023.104020

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. / Campa, Daniele; Gentiluomo, Manuel; Stein, Angelika et al.
In: Critical Reviews in Oncology/Hematology, Vol. 186, 104020, 01.06.2023.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - The PANcreatic Disease ReseArch (PANDoRA) consortium

T2 - Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

AU - Campa, Daniele

AU - Gentiluomo, Manuel

AU - Stein, Angelika

AU - Aoki, Mateus N. brega

AU - Oliverius, Martin

AU - Vodičková, Ludmila

AU - Jamroziak, Krzysztof

AU - Theodoropoulos, George

AU - Pasquali, Claudio

AU - Greenhalf, William

AU - Arcidiacono, Paolo Giorgio

AU - Uzunoglu, Faik

AU - Pezzilli, Raffaele

AU - Luchini, Claudio

AU - Puzzono, Marta

AU - Loos, Martin

AU - Giaccherini, Matteo

AU - Katzke, Verena

AU - Mambrini, Andrea

AU - Kiudeliene, Edita

AU - Federico, Kauffmann Emanuele

AU - Johansen, Julia

AU - Hussein, Tamás

AU - Mohelnikova-Duchonova, Beatrice

AU - van Eijck, Casper H. J.

AU - Brenner, Hermann

AU - Farinella, Riccardo

AU - Pérez, Juan Sainz

AU - Lovecek, Martin

AU - Büchler, Markus W.

AU - Hlavac, Viktor

AU - Izbicki, Jakob R.

AU - Hackert, Thilo

AU - Chammas, Roger

AU - Zerbi, Alessandro

AU - Lawlor, Rita

AU - Felici, Alessio

AU - Götz, Mara

AU - Capurso, Gabriele

AU - Ginocchi, Laura

AU - Gazouli, Maria

AU - Kupcinskas, Juozas

AU - Cavestro, Giulia Martina

AU - Vodicka, Pavel

AU - Moz, Stefania

AU - Neoptolemos, John P.

AU - Kunovsky, Lumir

AU - Bojesen, Stig E.

AU - Carrara, Silvia

AU - Gioffreda, Domenica

AU - Morkunas, Egidijus

AU - Abian, Olga

AU - Bunduc, Stefania

AU - Basso, Daniela

AU - Boggi, Ugo

AU - Wlodarczyk, Barbara

AU - Szentesi, Andrea

AU - Vanella, Giuseppe

AU - Chen, Inna

AU - Bijlsma, Maarten F.

AU - Kiudelis, Vytautas

AU - Landi, Stefano

AU - Schöttker, Ben

AU - Corradi, Chiara

AU - Giese, Nathalia

AU - Kaaks, Rudolf

AU - Peduzzi, Giulia

AU - Hegyi, P. ter

AU - Morelli, Luca

AU - Furbetta, Niccolò

AU - Soucek, Pavel

AU - Latiano, Anna

AU - Talar-Wojnarowska, Renata

AU - Lindgaard, Sidsel C.

AU - Dijk, Frederike

AU - Milanetto, Anna Caterina

AU - Tavano, Francesca

AU - Cervena, Klara

AU - Erőss, B. lint

AU - Testoni, Sabrina G.

AU - Verhagen-Oldenampsen, Judith H. E.

AU - Małecka-Wojciesko, Ewa

AU - Costello, Eithne

AU - Salvia, Roberto

AU - Maiello, Evaristo

AU - Ermini, Stefano

AU - Sperti, Cosimo

AU - Holleczek, Bernd

AU - Perri, Francesco

AU - Skieceviciene, Jurgita

AU - Archibugi, Livia

AU - Lucchesi, Maurizio

AU - Rizzato, Cosmeri

AU - Canzian, Federico

N1 - Funding Information: The research leading to these results has received funding from Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019—ID. 23672 project—P.I. Campa Daniele and IG 2021 ID – 26201 project P.I. Gabriele Capurso. PV, LV and KC acknowledge the support from the AZV , The Czech Ministry of Health , NU21–07–00247 and from Programme EXCELES , ID Project No. LX22NPO5102 . Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), Italy has received funding by the Italian Minister of Health , Ricerca Corrente program 2022–2024 , and by the and by the “5 × 1000″ voluntary contribution. Costello, E and Greenhalf, W are supported by grants from, Cancer Research UK ( C7690/A26881 , C18616/A25153 ) and Pancreatic Cancer UK . Sample accrual at the Amsterdam UMC was supported by the AMC Foundation . This article is based upon work from COST Action TRANSPAN, CA21116 , supported by COST (European Cooperation in Science and Technology). Publisher Copyright: © 2023

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

AB - Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

KW - Chronic pancreatitis

KW - Consortium

KW - Genetic epidemiology

KW - Intraductal papillary mucinous neoplasms

KW - Pancreatic cancer

KW - Pancreatic ductal adenocarcinoma

KW - Pancreatic neuroendocrine tumors

UR - http://www.scopus.com/inward/record.url?scp=85159706732&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.critrevonc.2023.104020

DO - https://doi.org/10.1016/j.critrevonc.2023.104020

M3 - Review article

C2 - 37164172

SN - 1040-8428

VL - 186

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

M1 - 104020

ER -

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

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Keywords

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