The relationship between inflammation and the coagulation system

Goda Choi; Marcus J. Schultz; Marcel Levi; Tom van der Poll

doi:https://doi.org/2006/09/smw-11059

The relationship between inflammation and the coagulation system

Goda Choi, Marcus J. Schultz, Marcel Levi, Tom van der Poll

Research output: Contribution to journal › Review article › Academic › peer-review

58 Citations (Scopus)

Abstract

Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old responses, there is extensive cross-talk between inflammation and coagulation in enabling an adequate immune response against potentially injurious stimuli. Immune cells are important in the initiation of coagulation pathways, while various inflammatory mediators are capable of altering haemostasis. Vice versa, coagulation proteases have significant immunomodulatory effects. Understanding the mechanisms involved in the crosstalk between inflammation and coagulation may yield new therapeutic strategies for human diseases

Original language	English
Pages (from-to)	139-144
Journal	Swiss medical weekly
Volume	136
Issue number	9-10
DOIs	https://doi.org/2006/09/smw-11059
Publication status	Published - 2006

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https://doi.org/2006/09/smw-11059

Cite this

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title = "The relationship between inflammation and the coagulation system",

abstract = "Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old responses, there is extensive cross-talk between inflammation and coagulation in enabling an adequate immune response against potentially injurious stimuli. Immune cells are important in the initiation of coagulation pathways, while various inflammatory mediators are capable of altering haemostasis. Vice versa, coagulation proteases have significant immunomodulatory effects. Understanding the mechanisms involved in the crosstalk between inflammation and coagulation may yield new therapeutic strategies for human diseases",

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AB - Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old responses, there is extensive cross-talk between inflammation and coagulation in enabling an adequate immune response against potentially injurious stimuli. Immune cells are important in the initiation of coagulation pathways, while various inflammatory mediators are capable of altering haemostasis. Vice versa, coagulation proteases have significant immunomodulatory effects. Understanding the mechanisms involved in the crosstalk between inflammation and coagulation may yield new therapeutic strategies for human diseases

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