TY - JOUR
T1 - The ultimate radiochemical nightmare
T2 - upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule
AU - van Uhm, Janneke I. M.
AU - Visser, Gerard W. M.
AU - van der Schans, Marcel J.
AU - Geldof, Albert A.
AU - Meuleman, Eric J. H.
AU - Nieuwenhuijzen, Jakko A.
PY - 2015
Y1 - 2015
N2 - Background: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabelled BoNT-A. In this paper, we report our feasibility study on labelling BoNT-A with high-dose iodine-125 (125I) via IODOGEN-coated BoNT-A method.
AB - Background: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabelled BoNT-A. In this paper, we report our feasibility study on labelling BoNT-A with high-dose iodine-125 (125I) via IODOGEN-coated BoNT-A method.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84923354486&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/25853011
U2 - https://doi.org/10.1186/s13550-015-0083-5
DO - https://doi.org/10.1186/s13550-015-0083-5
M3 - Article
C2 - 25853011
SN - 2191-219X
VL - 5
JO - EJNMMI Research
JF - EJNMMI Research
IS - 1
M1 - 5
ER -