TY - JOUR
T1 - The unfolded protein response and proteostasis in Alzheimer disease
T2 - Preferential activation of autophagy by endoplasmic reticulum stress
AU - Scheper, W.
AU - Nijholt, D.A.T.
AU - Hoozemans, J.J.M.
PY - 2011
Y1 - 2011
N2 - Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore proteostasis in the ER. Previously, we demonstrated that UPR activation is an early event in Alzheimer disease (AD) brain. In our recent work we investigated whether activation of the UPR is employed to enhance the capacity of the ubiquitin proteasome system or autophagy in neuronal cells. We showed that the levels, composition and activity of the proteasome are not regulated by the UPR. In contrast, UPR activation enhances autophagy and LC3 levels are increased in neurons displaying UPR activation in AD brain. Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain. © 2011 Landes Bioscience.
AB - Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore proteostasis in the ER. Previously, we demonstrated that UPR activation is an early event in Alzheimer disease (AD) brain. In our recent work we investigated whether activation of the UPR is employed to enhance the capacity of the ubiquitin proteasome system or autophagy in neuronal cells. We showed that the levels, composition and activity of the proteasome are not regulated by the UPR. In contrast, UPR activation enhances autophagy and LC3 levels are increased in neurons displaying UPR activation in AD brain. Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain. © 2011 Landes Bioscience.
U2 - https://doi.org/10.4161/auto.7.8.15761
DO - https://doi.org/10.4161/auto.7.8.15761
M3 - Short survey
SN - 1554-8627
VL - 7
SP - 910
EP - 911
JO - Autophagy
JF - Autophagy
IS - 8
ER -