Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Mia Ståhle; Johanna M. U. Silvola; Sanna Hellberg; Margreet de Vries; Paul H. A. Quax; Jeffrey Kroon; Petteri Rinne; Alwin de Jong; Heidi Liljenbäck; Nina Savisto; Anna Wickman; Erik S. G. Stroes; Seppo Ylä-Herttuala; Pekka Saukko; Tommy Abrahamsson; Knut Pettersson; Juhani Knuuti; Anne Roivainen; Antti Saraste

doi:https://doi.org/10.1016/j.jacbts.2020.01.008

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Mia Ståhle, Johanna M. U. Silvola, Sanna Hellberg, Margreet de Vries, Paul H. A. Quax, Jeffrey Kroon, Petteri Rinne, Alwin de Jong, Heidi Liljenbäck, Nina Savisto, Anna Wickman, Erik S. G. Stroes, Seppo Ylä-Herttuala, Pekka Saukko, Tommy Abrahamsson, Knut Pettersson, Juhani Knuuti, Anne Roivainen, Antti Saraste

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

Original language	English
Pages (from-to)	360-373
Number of pages	14
Journal	JACC. Basic to translational science
Volume	5
Issue number	4
Early online date	2020
DOIs	https://doi.org/10.1016/j.jacbts.2020.01.008
Publication status	Published - Apr 2020

Keywords

F-fluorodeoxyglucose positron emission tomography
atherosclerosis
coronary flow reserve
inflammation
phosphorylcholine

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https://doi.org/10.1016/j.jacbts.2020.01.008

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Ståhle, M., Silvola, J. M. U., Hellberg, S., de Vries, M., Quax, P. H. A., Kroon, J., Rinne, P., de Jong, A., Liljenbäck, H., Savisto, N., Wickman, A., Stroes, E. S. G., Ylä-Herttuala, S., Saukko, P., Abrahamsson, T., Pettersson, K., Knuuti, J., Roivainen, A., & Saraste, A. (2020). Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice. JACC. Basic to translational science, 5(4), 360-373. https://doi.org/10.1016/j.jacbts.2020.01.008

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title = "Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice",

abstract = "This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.",

keywords = "F-fluorodeoxyglucose positron emission tomography, atherosclerosis, coronary flow reserve, inflammation, phosphorylcholine",

author = "Mia St{\aa}hle and Silvola, {Johanna M. U.} and Sanna Hellberg and {de Vries}, Margreet and Quax, {Paul H. A.} and Jeffrey Kroon and Petteri Rinne and {de Jong}, Alwin and Heidi Liljenb{\"a}ck and Nina Savisto and Anna Wickman and Stroes, {Erik S. G.} and Seppo Yl{\"a}-Herttuala and Pekka Saukko and Tommy Abrahamsson and Knut Pettersson and Juhani Knuuti and Anne Roivainen and Antti Saraste",

year = "2020",

month = apr,

doi = "https://doi.org/10.1016/j.jacbts.2020.01.008",

language = "English",

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pages = "360--373",

journal = "JACC. Basic to translational science",

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Ståhle, M, Silvola, JMU, Hellberg, S, de Vries, M, Quax, PHA, Kroon, J, Rinne, P, de Jong, A, Liljenbäck, H, Savisto, N, Wickman, A, Stroes, ESG, Ylä-Herttuala, S, Saukko, P, Abrahamsson, T, Pettersson, K, Knuuti, J, Roivainen, A & Saraste, A 2020, 'Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice', JACC. Basic to translational science, vol. 5, no. 4, pp. 360-373. https://doi.org/10.1016/j.jacbts.2020.01.008

TY - JOUR

T1 - Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

AU - Ståhle, Mia

AU - Silvola, Johanna M. U.

AU - Hellberg, Sanna

AU - de Vries, Margreet

AU - Quax, Paul H. A.

AU - Kroon, Jeffrey

AU - Rinne, Petteri

AU - de Jong, Alwin

AU - Liljenbäck, Heidi

AU - Savisto, Nina

AU - Wickman, Anna

AU - Stroes, Erik S. G.

AU - Ylä-Herttuala, Seppo

AU - Saukko, Pekka

AU - Abrahamsson, Tommy

AU - Pettersson, Knut

AU - Knuuti, Juhani

AU - Roivainen, Anne

AU - Saraste, Antti

PY - 2020/4

Y1 - 2020/4

N2 - This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

AB - This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

KW - F-fluorodeoxyglucose positron emission tomography

KW - atherosclerosis

KW - coronary flow reserve

KW - inflammation

KW - phosphorylcholine

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U2 - https://doi.org/10.1016/j.jacbts.2020.01.008

DO - https://doi.org/10.1016/j.jacbts.2020.01.008

M3 - Article

C2 - 32368695

SN - 2452-302X

VL - 5

SP - 360

EP - 373

JO - JACC. Basic to translational science

JF - JACC. Basic to translational science

IS - 4

ER -

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

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