Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Kornelia Johann; Anna Lena Cremer; Alexander W. Fischer; Markus Heine; Eva Rial Pensado; Julia Resch; Sebastian Nock; Samuel Virtue; Lisbeth Harder; Rebecca Oelkrug; Mariana Astiz; Georg Brabant; Amy Warner; Antonio Vidal-Puig; Henrik Oster; Anita Boelen; Miguel López; Joerg Heeren; Jeffrey W. Dalley; Heiko Backes; Jens Mittag

doi:https://doi.org/10.1016/j.celrep.2019.05.054

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Kornelia Johann, Anna Lena Cremer, Alexander W. Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W. Dalley, Heiko BackesJens Mittag

Endocrinology Laboratory (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

74 Citations (Scopus)

Abstract

Thyroid hormone induces browning of white fat, but it is unclear whether this contributes to thermogenesis. Here, Johann et al. show that thyroid-hormone-induced beige fat is metabolically inactive due to lack of central stimulation and that the metabolic and thermogenic effects of the hormone are independent of UCP1.

Original language	English
Pages (from-to)	3385-3400.e3
Journal	Cell reports
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.05.054
Publication status	Published - 2019

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Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., Nock, S., Virtue, S., Harder, L., Oelkrug, R., Astiz, M., Brabant, G., Warner, A., Vidal-Puig, A., Oster, H., Boelen, A., López, M., Heeren, J., Dalley, J. W., ... Mittag, J. (2019). Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell reports, 27(11), 3385-3400.e3. https://doi.org/10.1016/j.celrep.2019.05.054

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title = "Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption",

abstract = "Thyroid hormone induces browning of white fat, but it is unclear whether this contributes to thermogenesis. Here, Johann et al. show that thyroid-hormone-induced beige fat is metabolically inactive due to lack of central stimulation and that the metabolic and thermogenic effects of the hormone are independent of UCP1.",

author = "Kornelia Johann and Cremer, {Anna Lena} and Fischer, {Alexander W.} and Markus Heine and Pensado, {Eva Rial} and Julia Resch and Sebastian Nock and Samuel Virtue and Lisbeth Harder and Rebecca Oelkrug and Mariana Astiz and Georg Brabant and Amy Warner and Antonio Vidal-Puig and Henrik Oster and Anita Boelen and Miguel L{\'o}pez and Joerg Heeren and Dalley, {Jeffrey W.} and Heiko Backes and Jens Mittag",

year = "2019",

doi = "https://doi.org/10.1016/j.celrep.2019.05.054",

language = "English",

volume = "27",

pages = "3385--3400.e3",

journal = "Cell reports",

issn = "2211-1247",

publisher = "Cell Press",

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Johann, K, Cremer, AL, Fischer, AW, Heine, M, Pensado, ER, Resch, J, Nock, S, Virtue, S, Harder, L, Oelkrug, R, Astiz, M, Brabant, G, Warner, A, Vidal-Puig, A, Oster, H, Boelen, A, López, M, Heeren, J, Dalley, JW, Backes, H & Mittag, J 2019, 'Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption', Cell reports, vol. 27, no. 11, pp. 3385-3400.e3. https://doi.org/10.1016/j.celrep.2019.05.054

TY - JOUR

T1 - Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

AU - Johann, Kornelia

AU - Cremer, Anna Lena

AU - Fischer, Alexander W.

AU - Heine, Markus

AU - Pensado, Eva Rial

AU - Resch, Julia

AU - Nock, Sebastian

AU - Virtue, Samuel

AU - Harder, Lisbeth

AU - Oelkrug, Rebecca

AU - Astiz, Mariana

AU - Brabant, Georg

AU - Warner, Amy

AU - Vidal-Puig, Antonio

AU - Oster, Henrik

AU - Boelen, Anita

AU - López, Miguel

AU - Heeren, Joerg

AU - Dalley, Jeffrey W.

AU - Backes, Heiko

AU - Mittag, Jens

PY - 2019

Y1 - 2019

N2 - Thyroid hormone induces browning of white fat, but it is unclear whether this contributes to thermogenesis. Here, Johann et al. show that thyroid-hormone-induced beige fat is metabolically inactive due to lack of central stimulation and that the metabolic and thermogenic effects of the hormone are independent of UCP1.

AB - Thyroid hormone induces browning of white fat, but it is unclear whether this contributes to thermogenesis. Here, Johann et al. show that thyroid-hormone-induced beige fat is metabolically inactive due to lack of central stimulation and that the metabolic and thermogenic effects of the hormone are independent of UCP1.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066439634&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31189119

U2 - https://doi.org/10.1016/j.celrep.2019.05.054

DO - https://doi.org/10.1016/j.celrep.2019.05.054

M3 - Article

C2 - 31189119

SN - 2211-1247

VL - 27

SP - 3385-3400.e3

JO - Cell reports

JF - Cell reports

IS - 11

ER -

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Abstract

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