Tissue distribution of the human CD97 EGF-TM7 receptor

L. H. Jaspars; W. Vos; G. Aust; R. A. van Lier; J. [=Jörg] Hamann

doi:https://doi.org/10.1034/j.1399-0039.2001.057004325.x

Tissue distribution of the human CD97 EGF-TM7 receptor

L. H. Jaspars, W. Vos, G. Aust, R. A. van Lier, J. [=Jörg] Hamann

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

CD97 is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) receptors. CD97 has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to CD55. Previous studies demonstrated the expression of CD97 on activated lymphocytes, monocytes, macrophages, granulocytes, and numerous haematopoietic and nonhaematopoietic cell lines. Here, we determined the cellular distribution of human CD97 in situ by immunohistochemistry (IH) and immunofluorescence (IF). Abundant expression of CD97 was detected on all types of macrophages and dendritic cells, except for microglia. Within the lymphoid lineage, most T cells but only a few B cells express CD97. Germinal centre B cells do not express the molecule. Except for smooth muscle cells, no staining was found on other cells outside the immune system. However, analysis of a restricted set of epithelial tumors revealed CD97 expression on the malignant cells in thyroid and gastrointestinal tract cancer

Original language	English
Pages (from-to)	325-331
Journal	Tissue antigens
Volume	57
Issue number	4
DOIs	https://doi.org/10.1034/j.1399-0039.2001.057004325.x
Publication status	Published - 2001

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https://doi.org/10.1034/j.1399-0039.2001.057004325.x

Cite this

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title = "Tissue distribution of the human CD97 EGF-TM7 receptor",

abstract = "CD97 is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) receptors. CD97 has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to CD55. Previous studies demonstrated the expression of CD97 on activated lymphocytes, monocytes, macrophages, granulocytes, and numerous haematopoietic and nonhaematopoietic cell lines. Here, we determined the cellular distribution of human CD97 in situ by immunohistochemistry (IH) and immunofluorescence (IF). Abundant expression of CD97 was detected on all types of macrophages and dendritic cells, except for microglia. Within the lymphoid lineage, most T cells but only a few B cells express CD97. Germinal centre B cells do not express the molecule. Except for smooth muscle cells, no staining was found on other cells outside the immune system. However, analysis of a restricted set of epithelial tumors revealed CD97 expression on the malignant cells in thyroid and gastrointestinal tract cancer",

author = "Jaspars, {L. H.} and W. Vos and G. Aust and {van Lier}, {R. A.} and Hamann, {J. [=J{\"o}rg]}",

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T1 - Tissue distribution of the human CD97 EGF-TM7 receptor

AU - Jaspars, L. H.

AU - Vos, W.

AU - Aust, G.

AU - van Lier, R. A.

AU - Hamann, J. [=Jörg]

PY - 2001

Y1 - 2001

N2 - CD97 is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) receptors. CD97 has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to CD55. Previous studies demonstrated the expression of CD97 on activated lymphocytes, monocytes, macrophages, granulocytes, and numerous haematopoietic and nonhaematopoietic cell lines. Here, we determined the cellular distribution of human CD97 in situ by immunohistochemistry (IH) and immunofluorescence (IF). Abundant expression of CD97 was detected on all types of macrophages and dendritic cells, except for microglia. Within the lymphoid lineage, most T cells but only a few B cells express CD97. Germinal centre B cells do not express the molecule. Except for smooth muscle cells, no staining was found on other cells outside the immune system. However, analysis of a restricted set of epithelial tumors revealed CD97 expression on the malignant cells in thyroid and gastrointestinal tract cancer

AB - CD97 is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) receptors. CD97 has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to CD55. Previous studies demonstrated the expression of CD97 on activated lymphocytes, monocytes, macrophages, granulocytes, and numerous haematopoietic and nonhaematopoietic cell lines. Here, we determined the cellular distribution of human CD97 in situ by immunohistochemistry (IH) and immunofluorescence (IF). Abundant expression of CD97 was detected on all types of macrophages and dendritic cells, except for microglia. Within the lymphoid lineage, most T cells but only a few B cells express CD97. Germinal centre B cells do not express the molecule. Except for smooth muscle cells, no staining was found on other cells outside the immune system. However, analysis of a restricted set of epithelial tumors revealed CD97 expression on the malignant cells in thyroid and gastrointestinal tract cancer

U2 - https://doi.org/10.1034/j.1399-0039.2001.057004325.x

DO - https://doi.org/10.1034/j.1399-0039.2001.057004325.x

M3 - Article

C2 - 11380941

SN - 0001-2815

VL - 57

SP - 325

EP - 331

JO - Tissue antigens

JF - Tissue antigens

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