TNFalpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS

J. Killestein; N. F. Kalkers; J. F. Meilof; F. Barkhof; R. A. van Lier; C. H. Polman

TNFalpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS

J. Killestein, N. F. Kalkers, J. F. Meilof, F. Barkhof, R. A. van Lier, C. H. Polman

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Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

Abstract

Reliable laboratory prognostic factors for MS are still lacking. The predictive value of markers of T-cell activation for long-term disease progression was investigated. Flow cytometry measurements were correlated to changes in Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS. A correlation was found between the percentage of tumor necrosis factor-alpha-producing CD4(+) T cells at baseline and the change in T2 lesion load during 3-year follow-up (r = 0.79, adjusted r(2) = 0.59, p = 0.001)

Original language	English
Pages (from-to)	1129-1131
Journal	Neurology
Volume	57
Issue number	6
Publication status	Published - 2001

Cite this

@article{2617439c1da4450889451996d1d3e90d,

title = "TNFalpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS",

abstract = "Reliable laboratory prognostic factors for MS are still lacking. The predictive value of markers of T-cell activation for long-term disease progression was investigated. Flow cytometry measurements were correlated to changes in Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS. A correlation was found between the percentage of tumor necrosis factor-alpha-producing CD4(+) T cells at baseline and the change in T2 lesion load during 3-year follow-up (r = 0.79, adjusted r(2) = 0.59, p = 0.001)",

author = "J. Killestein and Kalkers, {N. F.} and Meilof, {J. F.} and F. Barkhof and {van Lier}, {R. A.} and Polman, {C. H.}",

year = "2001",

language = "English",

volume = "57",

pages = "1129--1131",

journal = "Neurology",

issn = "0028-3878",

publisher = "American Academy of Neurology",

number = "6",

}

TY - JOUR

T1 - TNFalpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS

AU - Killestein, J.

AU - Kalkers, N. F.

AU - Meilof, J. F.

AU - Barkhof, F.

AU - van Lier, R. A.

AU - Polman, C. H.

PY - 2001

Y1 - 2001

N2 - Reliable laboratory prognostic factors for MS are still lacking. The predictive value of markers of T-cell activation for long-term disease progression was investigated. Flow cytometry measurements were correlated to changes in Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS. A correlation was found between the percentage of tumor necrosis factor-alpha-producing CD4(+) T cells at baseline and the change in T2 lesion load during 3-year follow-up (r = 0.79, adjusted r(2) = 0.59, p = 0.001)

AB - Reliable laboratory prognostic factors for MS are still lacking. The predictive value of markers of T-cell activation for long-term disease progression was investigated. Flow cytometry measurements were correlated to changes in Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS. A correlation was found between the percentage of tumor necrosis factor-alpha-producing CD4(+) T cells at baseline and the change in T2 lesion load during 3-year follow-up (r = 0.79, adjusted r(2) = 0.59, p = 0.001)

M3 - Article

C2 - 11571353

SN - 0028-3878

VL - 57

SP - 1129

EP - 1131

JO - Neurology

JF - Neurology

IS - 6

ER -