TY - JOUR
T1 - Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents
T2 - A position paper of the ESC Working Group on Myocardial Function
AU - Zacchigna, Serena
AU - Paldino, Alessia
AU - Falcão-Pires, Inês
AU - Daskalopoulos, Evangelos P.
AU - Dal Ferro, Matteo
AU - Vodret, Simone
AU - Lesizza, Pierluigi
AU - Cannatà, Antonio
AU - Miranda-Silva, Daniela
AU - Lourenço, André P.
AU - Pinamonti, Bruno
AU - Sinagra, Gianfranco
AU - Weinberger, Florian
AU - Eschenhagen, Thomas
AU - Carrier, Lucie
AU - Kehat, Izhak
AU - Tocchetti, Carlo G.
AU - Russo, Michele
AU - Ghigo, Alessandra
AU - Cimino, James
AU - Hirsch, Emilio
AU - Dawson, Dana
AU - Ciccarelli, Michele
AU - Oliveti, Marco
AU - Linke, Wolfgang A.
AU - Cuijpers, Ilona
AU - Heymans, Stephane
AU - Hamdani, Nazha
AU - De Boer, Martine
AU - Duncker, Dirk J.
AU - Kuster, Diederik
AU - Van Der Velden, Jolanda
AU - Beauloye, Christophe
AU - Bertrand, Luc
AU - Mayr, Manuel
AU - Giacca, Mauro
AU - Leuschner, Florian
AU - Backs, Johannes
AU - Thum, Thomas
N1 - Publisher Copyright: © 2020 Published on behalf of the European Society of Cardiology. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.
AB - Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.
KW - Animal models
KW - Diastolic function
KW - Echocardiography
KW - Standardization
KW - Systolic function
UR - http://www.scopus.com/inward/record.url?scp=85099721822&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/cvr/cvaa110
DO - https://doi.org/10.1093/cvr/cvaa110
M3 - Review article
C2 - 32365197
SN - 0008-6363
VL - 117
SP - 43
EP - 59
JO - Cardiovascular research
JF - Cardiovascular research
IS - 1
ER -