Trends in kidney transplantation rate across Europe: a study from the ERA Registry

Rianne Boenink; Anneke Kramer; Rosalie E. Tuinhout; Emilie Savoye; Anders Åsberg; Alma Idrizi; Julia Kerschbaum; Ieva Ziedina; Edita Ziginskiene; Emanuel Farrugia; Liliana Garneata; Elena V. Zakharova; Samira Bell; Miha Arnol; M. rten Segelmark; Kyriakos Ioannou; Kristine Hommel; Mai Rosenberg-Ots; Evgueniy Vazelov; Jaakko Helve; S. ndor Mihály; Runólfur Pálsson; Maurizio Nordio; Nikola Gjorgjievski; Aiko P. J. de Vries; Nurhan Seyahi; Winnie A. Magadi; Halima Resić; Aleh Kalachyk; Axel O. Rahmel; Ana A. Galvão; Radomir Naumovic; Torbjörn Lundgren; Mustafa Arici; Johan M. de Meester; Alberto Ortiz; Kitty J. Jager; Vianda S. Stel

doi:https://doi.org/10.1093/ndt/gfac333

Trends in kidney transplantation rate across Europe: a study from the ERA Registry

Rianne Boenink, Anneke Kramer, Rosalie E. Tuinhout, Emilie Savoye, Anders Åsberg, Alma Idrizi, Julia Kerschbaum, Ieva Ziedina, Edita Ziginskiene, Emanuel Farrugia, Liliana Garneata, Elena V. Zakharova, Samira Bell, Miha Arnol, M. rten Segelmark, Kyriakos Ioannou, Kristine Hommel, Mai Rosenberg-Ots, Evgueniy Vazelov, Jaakko HelveS. ndor Mihály, Runólfur Pálsson, Maurizio Nordio, Nikola Gjorgjievski, Aiko P. J. de Vries, Nurhan Seyahi, Winnie A. Magadi, Halima Resić, Aleh Kalachyk, Axel O. Rahmel, Ana A. Galvão, Radomir Naumovic, Torbjörn Lundgren, Mustafa Arici, Johan M. de Meester, Alberto Ortiz, Kitty J. Jager, Vianda S. Stel

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. METHODS: The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. RESULTS: The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). CONCLUSIONS: The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

Original language	English
Pages (from-to)	1528-1539
Number of pages	12
Journal	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume	38
Issue number	6
DOIs	https://doi.org/10.1093/ndt/gfac333
Publication status	Published - 1 Jun 2023

Keywords

Europe
kidney transplantation
trends

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https://doi.org/10.1093/ndt/gfac333

Cite this

Boenink, R., Kramer, A., Tuinhout, R. E., Savoye, E., Åsberg, A., Idrizi, A., Kerschbaum, J., Ziedina, I., Ziginskiene, E., Farrugia, E., Garneata, L., Zakharova, E. V., Bell, S., Arnol, M., Segelmark, M. R., Ioannou, K., Hommel, K., Rosenberg-Ots, M., Vazelov, E., ... Stel, V. S. (2023). Trends in kidney transplantation rate across Europe: a study from the ERA Registry. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 38(6), 1528-1539. https://doi.org/10.1093/ndt/gfac333

@article{a19995a1cd93470786ddb26281ff3594,

title = "Trends in kidney transplantation rate across Europe: a study from the ERA Registry",

abstract = "BACKGROUND: The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. METHODS: The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. RESULTS: The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). CONCLUSIONS: The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.",

keywords = "Europe, kidney transplantation, trends",

author = "Rianne Boenink and Anneke Kramer and Tuinhout, {Rosalie E.} and Emilie Savoye and Anders {\AA}sberg and Alma Idrizi and Julia Kerschbaum and Ieva Ziedina and Edita Ziginskiene and Emanuel Farrugia and Liliana Garneata and Zakharova, {Elena V.} and Samira Bell and Miha Arnol and Segelmark, {M. rten} and Kyriakos Ioannou and Kristine Hommel and Mai Rosenberg-Ots and Evgueniy Vazelov and Jaakko Helve and Mih{\'a}ly, {S. ndor} and Run{\'o}lfur P{\'a}lsson and Maurizio Nordio and Nikola Gjorgjievski and {de Vries}, {Aiko P. J.} and Nurhan Seyahi and Magadi, {Winnie A.} and Halima Resi{\'c} and Aleh Kalachyk and Rahmel, {Axel O.} and Galv{\~a}o, {Ana A.} and Radomir Naumovic and Torbj{\"o}rn Lundgren and Mustafa Arici and {de Meester}, {Johan M.} and Alberto Ortiz and Jager, {Kitty J.} and Stel, {Vianda S.}",

note = "Funding Information: We would like to thank the patients and the staff of the dialysis and transplant units for contributing the data via their national and regional renal registries to the ERA Registry and the GODT. Furthermore, we gratefully acknowledge the following registries and persons for their contribution of the data: Albanian Renal Registry (M. Rroji and E. Likaj); Austrian Dialysis and Transplant Registry (OEDTR) (F. Engler, R. Kramar, G. Mayer, and the Austrian Society of Nephrology); Belarus Renal Registry (K.S. Komissarov and K.S. Kamisarau); Dutch-speaking Belgian Society of Nephrology (NBVN) (M. Couttenye and F. Schroven); French-speaking Belgian Society of Nephrology (GNFB) (J.M. des Grottes and F. Collart); Renal Registry Bosnia and Herzegovina; Cyprus Renal Registry (A. Pastelli and L Yioukas); Czech Republic: Registry of Dialysis Patients (RDP) (F. Lopot, I. Rychl{\'i}k and J. Potucek); Danish Nephrology Registry (DNS); Estonian Society of Nephrology ({\"U}. Pechter and K. Lilienthal); Finnish Registry for Kidney Diseases (P. Finne and H. Niemel{\"a}); France: The Epidemiology and Information Network in Nephrology (REIN) (M. Lassalle and C. Couchoud); Hellenic Renal Registry (G. Moustakas); Icelandic End-Stage Renal Disease Registry; Montenegro Renal Registry (M. Ratkovic, D. Radunovi{\'c} and F. Tomovi{\'c}); Italian Registry of Dialysis and Transplantation (RIDT) (A. Limido and M. Postorino); Latvian Renal Registry (V. Kuzema, A. Popovam and A. Pētersons); Lithuanian Renal Registry (V. Vainauskas and I. Nedzelskiene); North Macedonian Renal Registry (O. Stojceva and R.I. Bushljetik); Norwegian Renal Registry (A.V. Reis{\ae}ter); Portuguese Renal Registry (A. Ferreira); Romanian Renal Registry (RRR) (G. Mircescu, and E. Podgoreanu); Russian Renal Registry (A. Andrusev and N. Tomilina); Renal Registry in Serbia (M. Lausevic, all of the Serbian renal units, and the Serbian Society of Nephrology); Slovakian Renal Registry (I. Lajdov{\'a}, V. Spustov{\'a} and M.J. Rosenberger); Spain Renal Registry (B. Mahillo Dur{\'a}n and M.O. Valent{\'i}n Mu{\~n}oz); Swedish Renal Registry (SRR) (K.G. Pr{\"u}tz, M. Stendahl, M. Evans, S. Sch{\"o}n and H. Rydell); Swiss Dialysis Registry (P. Amb{\"u}hl and R. Guidotti); Dutch Renal Registry (RENINE) (L. Heuveling, S. Vogelaar and M. ten Dam); Registry of the Nephrology, Dialysis and Transplantation in Turkey (TSNNR) (K. Ate{\c s} and G. S{\"u}leymanlar); UK Renal Registry (all the staff of the UK Renal Registry and of the renal units submitting data); Scottish Renal Registry (SRR) (All of the Scottish renal units); and the other ERA Registry committee members not mentioned above for their advice in the analysis and the drafting of this paper: C. Wanner, P. Amb{\"u}hl, P.M. Ferraro, S.A. Bakkaloglu, J. Helve, J.E. S{\'a}nchez-Alvarez, S.S. S{\o}rensen and E. Vidal. The ERA Registry is funded by the European Renal Association (ERA). This article was written by Rianne Boenink et al. on behalf of the ERA Registry which is an official body of the ERA. Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2023",

month = jun,

day = "1",

doi = "https://doi.org/10.1093/ndt/gfac333",

language = "English",

volume = "38",

pages = "1528--1539",

journal = "Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association",

issn = "0931-0509",

publisher = "Oxford University Press",

number = "6",

}

Boenink, R , Kramer, A, Tuinhout, RE, Savoye, E, Åsberg, A, Idrizi, A, Kerschbaum, J, Ziedina, I, Ziginskiene, E, Farrugia, E, Garneata, L, Zakharova, EV, Bell, S, Arnol, M, Segelmark, MR, Ioannou, K, Hommel, K, Rosenberg-Ots, M, Vazelov, E, Helve, J, Mihály, SN, Pálsson, R, Nordio, M, Gjorgjievski, N, de Vries, APJ, Seyahi, N, Magadi, WA, Resić, H, Kalachyk, A, Rahmel, AO, Galvão, AA, Naumovic, R, Lundgren, T, Arici, M, de Meester, JM, Ortiz, A, Jager, KJ & Stel, VS 2023, 'Trends in kidney transplantation rate across Europe: a study from the ERA Registry', Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, vol. 38, no. 6, pp. 1528-1539. https://doi.org/10.1093/ndt/gfac333

Trends in kidney transplantation rate across Europe: a study from the ERA Registry. / Boenink, Rianne ; Kramer, Anneke; Tuinhout, Rosalie E. et al.
In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 38, No. 6, 01.06.2023, p. 1528-1539.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Trends in kidney transplantation rate across Europe

T2 - a study from the ERA Registry

AU - Boenink, Rianne

AU - Kramer, Anneke

AU - Tuinhout, Rosalie E.

AU - Savoye, Emilie

AU - Åsberg, Anders

AU - Idrizi, Alma

AU - Kerschbaum, Julia

AU - Ziedina, Ieva

AU - Ziginskiene, Edita

AU - Farrugia, Emanuel

AU - Garneata, Liliana

AU - Zakharova, Elena V.

AU - Bell, Samira

AU - Arnol, Miha

AU - Segelmark, M. rten

AU - Ioannou, Kyriakos

AU - Hommel, Kristine

AU - Rosenberg-Ots, Mai

AU - Vazelov, Evgueniy

AU - Helve, Jaakko

AU - Mihály, S. ndor

AU - Pálsson, Runólfur

AU - Nordio, Maurizio

AU - Gjorgjievski, Nikola

AU - de Vries, Aiko P. J.

AU - Seyahi, Nurhan

AU - Magadi, Winnie A.

AU - Resić, Halima

AU - Kalachyk, Aleh

AU - Rahmel, Axel O.

AU - Galvão, Ana A.

AU - Naumovic, Radomir

AU - Lundgren, Torbjörn

AU - Arici, Mustafa

AU - de Meester, Johan M.

AU - Ortiz, Alberto

AU - Jager, Kitty J.

AU - Stel, Vianda S.

N1 - Funding Information: We would like to thank the patients and the staff of the dialysis and transplant units for contributing the data via their national and regional renal registries to the ERA Registry and the GODT. Furthermore, we gratefully acknowledge the following registries and persons for their contribution of the data: Albanian Renal Registry (M. Rroji and E. Likaj); Austrian Dialysis and Transplant Registry (OEDTR) (F. Engler, R. Kramar, G. Mayer, and the Austrian Society of Nephrology); Belarus Renal Registry (K.S. Komissarov and K.S. Kamisarau); Dutch-speaking Belgian Society of Nephrology (NBVN) (M. Couttenye and F. Schroven); French-speaking Belgian Society of Nephrology (GNFB) (J.M. des Grottes and F. Collart); Renal Registry Bosnia and Herzegovina; Cyprus Renal Registry (A. Pastelli and L Yioukas); Czech Republic: Registry of Dialysis Patients (RDP) (F. Lopot, I. Rychlík and J. Potucek); Danish Nephrology Registry (DNS); Estonian Society of Nephrology (Ü. Pechter and K. Lilienthal); Finnish Registry for Kidney Diseases (P. Finne and H. Niemelä); France: The Epidemiology and Information Network in Nephrology (REIN) (M. Lassalle and C. Couchoud); Hellenic Renal Registry (G. Moustakas); Icelandic End-Stage Renal Disease Registry; Montenegro Renal Registry (M. Ratkovic, D. Radunović and F. Tomović); Italian Registry of Dialysis and Transplantation (RIDT) (A. Limido and M. Postorino); Latvian Renal Registry (V. Kuzema, A. Popovam and A. Pētersons); Lithuanian Renal Registry (V. Vainauskas and I. Nedzelskiene); North Macedonian Renal Registry (O. Stojceva and R.I. Bushljetik); Norwegian Renal Registry (A.V. Reisæter); Portuguese Renal Registry (A. Ferreira); Romanian Renal Registry (RRR) (G. Mircescu, and E. Podgoreanu); Russian Renal Registry (A. Andrusev and N. Tomilina); Renal Registry in Serbia (M. Lausevic, all of the Serbian renal units, and the Serbian Society of Nephrology); Slovakian Renal Registry (I. Lajdová, V. Spustová and M.J. Rosenberger); Spain Renal Registry (B. Mahillo Durán and M.O. Valentín Muñoz); Swedish Renal Registry (SRR) (K.G. Prütz, M. Stendahl, M. Evans, S. Schön and H. Rydell); Swiss Dialysis Registry (P. Ambühl and R. Guidotti); Dutch Renal Registry (RENINE) (L. Heuveling, S. Vogelaar and M. ten Dam); Registry of the Nephrology, Dialysis and Transplantation in Turkey (TSNNR) (K. Ateş and G. Süleymanlar); UK Renal Registry (all the staff of the UK Renal Registry and of the renal units submitting data); Scottish Renal Registry (SRR) (All of the Scottish renal units); and the other ERA Registry committee members not mentioned above for their advice in the analysis and the drafting of this paper: C. Wanner, P. Ambühl, P.M. Ferraro, S.A. Bakkaloglu, J. Helve, J.E. Sánchez-Alvarez, S.S. Sørensen and E. Vidal. The ERA Registry is funded by the European Renal Association (ERA). This article was written by Rianne Boenink et al. on behalf of the ERA Registry which is an official body of the ERA. Publisher Copyright: © The Author(s) 2023.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - BACKGROUND: The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. METHODS: The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. RESULTS: The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). CONCLUSIONS: The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

AB - BACKGROUND: The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. METHODS: The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. RESULTS: The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). CONCLUSIONS: The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

KW - Europe

KW - kidney transplantation

KW - trends

UR - http://www.scopus.com/inward/record.url?scp=85160877129&partnerID=8YFLogxK

U2 - https://doi.org/10.1093/ndt/gfac333

DO - https://doi.org/10.1093/ndt/gfac333

M3 - Article

C2 - 36610723

SN - 0931-0509

VL - 38

SP - 1528

EP - 1539

JO - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

IS - 6

ER -

Trends in kidney transplantation rate across Europe: a study from the ERA Registry

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