TY - JOUR
T1 - Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke
T2 - A prospective analysis in 11,560 adults
AU - Joshi, Roshni
AU - Wannamethee, S. Goya
AU - Engmann, Jorgen
AU - Gaunt, Tom
AU - Lawlor, Deborah A.
AU - Price, Jackie
AU - Papacosta, Olia
AU - Shah, Tina
AU - Tillin, Therese
AU - Chaturvedi, Nishi
AU - Kivimaki, Mika
AU - Kuh, Diana
AU - Kumari, Meena
AU - Hughes, Alun D.
AU - Casas, Juan P.
AU - Humphries, Steve
AU - Hingorani, Aroon D.
AU - Schmidt, A. Floriaan
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Aims: Elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease; however, there is uncertainty about the role of total triglycerides and the individual triglyceride-containing lipoprotein sub-fractions. We measured 14 triglyceride-containing lipoprotein sub-fractions using nuclear magnetic resonance and examined associations with coronary heart disease and stroke. Methods: Triglyceride-containing sub-fraction measures were available in 11,560 participants from the three UK cohorts free of coronary heart disease and stroke at baseline. Multivariable logistic regression was used to estimate the association of each sub-fraction with coronary heart disease and stroke expressed as the odds ratio per standard deviation increment in the corresponding measure. Results: The 14 triglyceride-containing sub-fractions were positively correlated with one another and with total triglycerides, and inversely correlated with high-density lipoprotein cholesterol (HDL-C). Thirteen sub-fractions were positively associated with coronary heart disease (odds ratio in the range 1.12 to 1.22), with the effect estimates for coronary heart disease being comparable in subgroup analysis of participants with and without type 2 diabetes, and were attenuated after adjustment for HDL-C and LDL-C. There was no evidence for a clear association of any triglyceride lipoprotein sub-fraction with stroke. Conclusions: Triglyceride sub-fractions are associated with increased risk of coronary heart disease but not stroke, with attenuation of effects on adjustment for HDL-C and LDL-C.
AB - Aims: Elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease; however, there is uncertainty about the role of total triglycerides and the individual triglyceride-containing lipoprotein sub-fractions. We measured 14 triglyceride-containing lipoprotein sub-fractions using nuclear magnetic resonance and examined associations with coronary heart disease and stroke. Methods: Triglyceride-containing sub-fraction measures were available in 11,560 participants from the three UK cohorts free of coronary heart disease and stroke at baseline. Multivariable logistic regression was used to estimate the association of each sub-fraction with coronary heart disease and stroke expressed as the odds ratio per standard deviation increment in the corresponding measure. Results: The 14 triglyceride-containing sub-fractions were positively correlated with one another and with total triglycerides, and inversely correlated with high-density lipoprotein cholesterol (HDL-C). Thirteen sub-fractions were positively associated with coronary heart disease (odds ratio in the range 1.12 to 1.22), with the effect estimates for coronary heart disease being comparable in subgroup analysis of participants with and without type 2 diabetes, and were attenuated after adjustment for HDL-C and LDL-C. There was no evidence for a clear association of any triglyceride lipoprotein sub-fraction with stroke. Conclusions: Triglyceride sub-fractions are associated with increased risk of coronary heart disease but not stroke, with attenuation of effects on adjustment for HDL-C and LDL-C.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078945298&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31996015
U2 - https://doi.org/10.1177/2047487319899621
DO - https://doi.org/10.1177/2047487319899621
M3 - Article
C2 - 31996015
SN - 2047-4873
VL - 27
SP - 1617
EP - 1626
JO - European journal of preventive cardiology
JF - European journal of preventive cardiology
IS - 15
ER -