Tumour-reactive B cells and antibody responses after allogeneic haematopoietic cell transplantation

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Abstract

For many high-risk haematologic malignancies, such as acute myeloid leukaemia, the success of therapy relies mainly on invoking a curative antitumour immune response. This can be achieved by inducing a graft-versus-leukaemia response following allogeneic haematopoietic cell transplantation. While the contribution of T cells and natural killer cells to graft-versus-leukaemia responses is established, the contribution of B cells and antibodies is relatively unexplored. This article reviews what is known about the contribution of B cells and tumour-specific antibody responses to a successful graft-versus-leukaemia response leading to eradication of the tumour.
Original languageEnglish
Pages (from-to)15-22
JournalImmuno-Oncology and Technology
Volume7
DOIs
Publication statusPublished - 1 Sep 2020

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