TY - JOUR
T1 - Two sides of the same coin
T2 - Protective versus pathogenic CD4+ resident memory T cells
AU - Oja, Anna E.
AU - van Lier, René A. W.
AU - Hombrink, Pleun
N1 - Funding Information: Acknowledgments Funding: This project was funded by Sanquin PPO project supported by the Dutch government and an NWO-Veni 2017 grant. Author contributions: All authors wrote and edited the manuscript. Competing interests: The authors declare that they have no competing interests. Publisher Copyright: © 2022 The Authors.
PY - 2022/4/8
Y1 - 2022/4/8
N2 - The ability of the adaptive immune system to form memory is key to providing protection against secondary infections. Resident memory T cells (TRM) are specialized T cell populations that reside within tissue sites where they await reencounter with their cognate antigen. TRM are distinct from circulating memory cells, including central and effector memory T cells, both functionally and transcriptionally. Since the discovery of TRM, most research has focused on CD8+ TRM, despite that CD4+ TRM are also abundant in most tissues. In the past few years, more evidence has emerged that CD4+ TRM can contribute both protective and pathogenic roles in disease. A complexity inherent to the CD4+ TRM field is the ability of CD4+ T cells to polarize into a multitude of distinct subsets and recognize not only viruses and intracellular bacteria but also extracellular bacteria, fungi, and parasites. In this review, we outline the key features of CD4+ TRM in health and disease, including their contributions to protection against SARS-CoV-2 and potential contributions to immunopathology associated with COVID-19.
AB - The ability of the adaptive immune system to form memory is key to providing protection against secondary infections. Resident memory T cells (TRM) are specialized T cell populations that reside within tissue sites where they await reencounter with their cognate antigen. TRM are distinct from circulating memory cells, including central and effector memory T cells, both functionally and transcriptionally. Since the discovery of TRM, most research has focused on CD8+ TRM, despite that CD4+ TRM are also abundant in most tissues. In the past few years, more evidence has emerged that CD4+ TRM can contribute both protective and pathogenic roles in disease. A complexity inherent to the CD4+ TRM field is the ability of CD4+ T cells to polarize into a multitude of distinct subsets and recognize not only viruses and intracellular bacteria but also extracellular bacteria, fungi, and parasites. In this review, we outline the key features of CD4+ TRM in health and disease, including their contributions to protection against SARS-CoV-2 and potential contributions to immunopathology associated with COVID-19.
UR - http://www.scopus.com/inward/record.url?scp=85127887460&partnerID=8YFLogxK
U2 - https://doi.org/10.1126/sciimmunol.abf9393
DO - https://doi.org/10.1126/sciimmunol.abf9393
M3 - Article
C2 - 35394815
SN - 2470-9468
VL - 7
SP - eabf9393
JO - Science immunology
JF - Science immunology
IS - 70
M1 - abf9393
ER -