Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease

Serge A.R.B. Rombouts; Frederik Barkhof; Menno P. Witter; Philip Scheltens

doi:https://doi.org/10.1016/S0304-3940(00)01067-3

Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease

Serge A.R.B. Rombouts, Frederik Barkhof, Menno P. Witter, Philip Scheltens

Research output: Contribution to journal › Article › Academic › peer-review

142 Citations (Scopus)

Abstract

In patients with Alzheimer's disease, substantial tissue loss occurs in the medial temporal lobe. In this study, we applied a voxel-based, unbiased whole-brain analysis method to compare magnetic resonance imaging scans of seven patients with Alzheimer's disease and seven healthy elderly controls. Images were transformed to standard coordinate space and tested for gray matter loss in patients. We found symmetrical decreases of gray matter in patients in the hippocampus, and, unexpectedly, also in the head of the caudate nucleus and the insula. The exact role of these two structures in the symptomatology of Alzheimer's disease deserves further attention. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	231-233
Number of pages	3
Journal	Neuroscience letters
Volume	285
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(00)01067-3
Publication status	Published - 19 May 2000

Keywords

Alzheimer's disease
Atrophy
Dementia
Hippocampus
Magnetic resonance imaging

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AU - Witter, Menno P.

AU - Scheltens, Philip

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AB - In patients with Alzheimer's disease, substantial tissue loss occurs in the medial temporal lobe. In this study, we applied a voxel-based, unbiased whole-brain analysis method to compare magnetic resonance imaging scans of seven patients with Alzheimer's disease and seven healthy elderly controls. Images were transformed to standard coordinate space and tested for gray matter loss in patients. We found symmetrical decreases of gray matter in patients in the hippocampus, and, unexpectedly, also in the head of the caudate nucleus and the insula. The exact role of these two structures in the symptomatology of Alzheimer's disease deserves further attention. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Alzheimer's disease

KW - Atrophy

KW - Dementia

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Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease

Abstract

Keywords

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