@inproceedings{2ba3196dc0744831941975cad23d9dd8,
title = "Understanding the Dynamics of the Proliferative Phase in Local Burn Wound Healing: A Computational Model",
abstract = "Understanding the dynamic processes that underlie burn wound healing is a complex endeavor that requires advanced computational approaches. The proliferative phase in burn wounds is critical for the closure of the burn wound. We present a novel model that uses a set of coupled ordinary differential equations that predict intricate interactions between different cell types, cytokines, growth factors, and proteins during the proliferative phase of wound healing after burn injury. We simulated the model for 30 weeks and were able to predict cell and molecular dynamics in this intricate phase of burn wound healing. We achieved biologically sensible results and were able to identify fibroblasts, myofibroblasts, and collagen types III and I as crucial parameters that drive the proliferative phase in burn wounds.",
author = "Bumbuc, {Roland V.} and Korkmaz, {H. Ibrahim} and {van Zuijlen}, {P. P. M.} and Louis Vermeulen and Sheraton, {Vivek M.}",
year = "2023",
doi = "10.1109/BIBM58861.2023.10385875",
language = "English",
series = "Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "3676--3683",
editor = "Xingpeng Jiang and Haiying Wang and Reda Alhajj and Xiaohua Hu and Felix Engel and Mufti Mahmud and Nadia Pisanti and Xuefeng Cui and Hong Song",
booktitle = "Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023",
address = "United States",
note = "2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023 ; Conference date: 05-12-2023 Through 08-12-2023",
}