@article{8b34851e1d8247288c50d482e7ced15e,
title = "Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)",
abstract = "Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.",
keywords = "assisted ventilation, critical care, pneumonia",
author = "{van Oort}, {Pouline Mp} and Nijsen, {Tamara M.} and White, {Iain R.} and Knobel, {Hugo H.} and Timothy Felton and Nicholas Rattray and Oluwasola Lawal and Murtaza Bulut and Waqar Ahmed and Antonio Artigas and Povoa, {Pedro R.} and Ignacio Martin-Loeches and Hans Weda and Royston Goodacre and Schultz, {Marcus J.} and Dark, {Paul M.} and Fowler, {Stephen J.} and Bos, {Lieuwe D.}",
note = "Funding Information: Funding The project was funded by the European Union FP7 Marie Curie Actions, under the Industry-Academia Partnerships and Pathways (IAPP) programme (MC-IAPP BreathDx 611951). IRW, TF, PMD and SJF were supported by the NIHR Manchester Biochemical Research Centre. Competing interests None declared. Patient consent for publication Not required. Publisher Copyright: {\textcopyright}",
year = "2022",
month = jan,
day = "1",
doi = "https://doi.org/10.1136/thoraxjnl-2021-217362",
language = "English",
volume = "77",
pages = "79--81",
journal = "Thorax",
issn = "0040-6376",
publisher = "BMJ Publishing Group",
number = "1",
}