TY - JOUR
T1 - Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience
AU - Verdonk, Franck
AU - Feyaerts, Dorien
AU - Badenes, Rafael
AU - Bastarache, Julie A.
AU - Bouglé, Adrien
AU - Ely, Wesley
AU - Gaudilliere, Brice
AU - Howard, Christopher
AU - Kotfis, Katarzyna
AU - Lautrette, Alexandre
AU - le Dorze, Matthieu
AU - Mankidy, Babith Joseph
AU - Matthay, Michael A.
AU - Morgan, Christopher K.
AU - Mazeraud, Aurélien
AU - Patel, Brijesh V.
AU - Pattnaik, Rajyabardhan
AU - Reuter, Jean
AU - Schultz, Marcus J.
AU - Sharshar, Tarek
AU - Shrestha, Gentle S.
AU - Verdonk, Charles
AU - Ware, Lorraine B.
AU - Pirracchio, Romain
AU - Jabaudon, Matthieu
N1 - Funding Information: This work was supported by the Department of Perioperative Medicine , CHU Clermont-Ferrand, Clermont-Ferrand, France. Publisher Copyright: © 2022 The Authors
PY - 2022/10/1
Y1 - 2022/10/1
N2 - While the coronavirus disease 2019 (COVID-19) pandemic placed a heavy burden on healthcare systems worldwide, it also induced urgent mobilisation of research teams to develop treatments preventing or curing the disease and its consequences. It has, therefore, challenged critical care research to rapidly focus on specific fields while forcing critical care physicians to make difficult ethical decisions. This narrative review aims to summarise critical care research —from organisation to research fields— in this pandemic setting and to highlight opportunities to improve research efficiency in the future, based on what is learned from COVID-19. This pressure on research revealed, i.e., (i) the need to harmonise regulatory processes between countries, allowing simplified organisation of international research networks to improve their efficiency in answering large-scale questions; (ii) the importance of developing translational research from which therapeutic innovations can emerge; (iii) the need for improved triage and predictive scores to rationalise admission to the intensive care unit. In this context, key areas for future critical care research and better pandemic preparedness are artificial intelligence applied to healthcare, characterisation of long-term symptoms, and ethical considerations. Such collaborative research efforts should involve groups from both high and low-to-middle income countries to propose worldwide solutions. As a conclusion, stress tests on healthcare organisations should be viewed as opportunities to design new research frameworks and strategies. Worldwide availability of research networks ready to operate is essential to be prepared for next pandemics. Importantly, researchers and physicians should prioritise realistic and ethical goals for both clinical care and research.
AB - While the coronavirus disease 2019 (COVID-19) pandemic placed a heavy burden on healthcare systems worldwide, it also induced urgent mobilisation of research teams to develop treatments preventing or curing the disease and its consequences. It has, therefore, challenged critical care research to rapidly focus on specific fields while forcing critical care physicians to make difficult ethical decisions. This narrative review aims to summarise critical care research —from organisation to research fields— in this pandemic setting and to highlight opportunities to improve research efficiency in the future, based on what is learned from COVID-19. This pressure on research revealed, i.e., (i) the need to harmonise regulatory processes between countries, allowing simplified organisation of international research networks to improve their efficiency in answering large-scale questions; (ii) the importance of developing translational research from which therapeutic innovations can emerge; (iii) the need for improved triage and predictive scores to rationalise admission to the intensive care unit. In this context, key areas for future critical care research and better pandemic preparedness are artificial intelligence applied to healthcare, characterisation of long-term symptoms, and ethical considerations. Such collaborative research efforts should involve groups from both high and low-to-middle income countries to propose worldwide solutions. As a conclusion, stress tests on healthcare organisations should be viewed as opportunities to design new research frameworks and strategies. Worldwide availability of research networks ready to operate is essential to be prepared for next pandemics. Importantly, researchers and physicians should prioritise realistic and ethical goals for both clinical care and research.
KW - COVID-19
KW - Critical care
KW - Pandemic
KW - Perspectives
KW - Research
UR - http://www.scopus.com/inward/record.url?scp=85136598511&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.accpm.2022.101121
DO - https://doi.org/10.1016/j.accpm.2022.101121
M3 - Review article
C2 - 35781076
SN - 2352-5568
VL - 41
JO - Anaesthesia, critical care and pain medicine
JF - Anaesthesia, critical care and pain medicine
IS - 5
M1 - 101121
ER -