Abstract
INTRODUCTION: Immunotherapeutic agents against amyloid beta (Aβ) are associated with adverse events, including amyloid-related imaging abnormalities with edema and effusion (ARIA-E). Recently, a magnetic resonance imaging (MRI) rating scale was developed for ARIA-E detection and classification. The aim of this study was to validate the use of this rating scale in a larger patient group with multiple raters. METHODS: MRI scans of 75 patients (29 with known ARIA-E and 46 control subjects) were analyzed by five neuroradiologists with different degrees of expertise, according to the ARIA-E rating scale. For each patient, we included a baseline and a follow-up fluid-attenuated inversion recovery image. Interrater agreement was calculated using intraclass correlation coefficient (ICC). RESULTS: On average, 4.1% of the ARIA-E cases were missed. We observed a high interrater agreement for scores of sulcal hyperintensity (SH; ICC =.915; 95% CI 85–95) and for the combined scores of the 2 ARIA-E findings, parenchymal hyperintensity (PH) and SH (ICC =.878; 95% CI 79–93). A slightly lower agreement for PH (ICC =.678; 95% CI 51–81) was noted. CONCLUSION: The ARIA-E rating scale is a simple tool to evaluate the extent of ARIA-E in patients recruited into Aβ-lowering therapeutic trials. It shows high interrater agreement among raters with different degrees of expertise.
Original language | English |
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Pages (from-to) | 318-325 |
Number of pages | 8 |
Journal | Journal of neuroimaging |
Volume | 27 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 May 2017 |
Keywords
- ARIA (amyloid-related imaging abnormalities)
- Alzheimer's disease (AD)
- MRI (magnetic resonance imaging)
- amyloid beta (Aβ)
- immunotherapy