TY - JOUR
T1 - Value of health-related quality of life to predict disability course in multiple sclerosis
AU - Visschedijk, M. A.J.
AU - Uitdehaag, B. M.J.
AU - Klein, M.
AU - Van Der Ploeg, E.
AU - Collette, E. H.
AU - Vleugels, L.
AU - Pfennings, L. E.M.A.
AU - Hoogervorst, E. L.J.
AU - Van Der Ploeg, H. M.
AU - Polman, C. H.
PY - 2004/12/14
Y1 - 2004/12/14
N2 - Objective: To determine the value of health-related quality of life (HRQoL) to predict change in disability status in patients with multiple sclerosis (MS). Methods: Over a 5-year period, data were collected on HRQoL (Medical Outcomes Study Short Form-36 Health Survey) and disability status (Expanded Disability Status Scale) from a heterogeneous group of 81 Dutch-speaking patients with MS. Results: Multivariate logistic regression analysis showed that HRQoL in the domains of Physical Functioning and Role-Physical Functioning is a significant predictor of change in disability status. Conclusions: A patient's subjectively perceived health-related quality of life may not be only a clinically and psychosocially meaningful outcome per se but may also be a predictor of objective outcomes such as change in disability status over a substantial period of time.
AB - Objective: To determine the value of health-related quality of life (HRQoL) to predict change in disability status in patients with multiple sclerosis (MS). Methods: Over a 5-year period, data were collected on HRQoL (Medical Outcomes Study Short Form-36 Health Survey) and disability status (Expanded Disability Status Scale) from a heterogeneous group of 81 Dutch-speaking patients with MS. Results: Multivariate logistic regression analysis showed that HRQoL in the domains of Physical Functioning and Role-Physical Functioning is a significant predictor of change in disability status. Conclusions: A patient's subjectively perceived health-related quality of life may not be only a clinically and psychosocially meaningful outcome per se but may also be a predictor of objective outcomes such as change in disability status over a substantial period of time.
UR - http://www.scopus.com/inward/record.url?scp=10444282254&partnerID=8YFLogxK
U2 - https://doi.org/10.1212/01.WNL.0000145769.51420.ED
DO - https://doi.org/10.1212/01.WNL.0000145769.51420.ED
M3 - Article
C2 - 15596748
SN - 0028-3878
VL - 63
SP - 2046
EP - 2050
JO - Neurology
JF - Neurology
IS - 11
ER -