TY - JOUR
T1 - Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress
AU - Gouverneur, M.
AU - Berg, B.
AU - Nieuwdorp, M.
AU - Stroes, E.
AU - Vink, H.
PY - 2006
Y1 - 2006
N2 - The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagulation and leucocyte adhesion, by contributing to the vascular permeability barrier and by mediating shear stress-induced NO release. In this review, we will focus on the relationship between fluid shear stress and the endothelial glycocalyx. We will address the hypothesis that modulation of glycocalyx synthesis by fluid shear stress may contribute to thinner glycocalyces, and therefore more vulnerable endothelium, at lesion-prone sites of arterial bifurcations. Finally, we will discuss the effects of known atherogenic stimuli such as hyperglycaemia on whole body glycocalyx volume in humans and its effect on endothelial function
AB - The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagulation and leucocyte adhesion, by contributing to the vascular permeability barrier and by mediating shear stress-induced NO release. In this review, we will focus on the relationship between fluid shear stress and the endothelial glycocalyx. We will address the hypothesis that modulation of glycocalyx synthesis by fluid shear stress may contribute to thinner glycocalyces, and therefore more vulnerable endothelium, at lesion-prone sites of arterial bifurcations. Finally, we will discuss the effects of known atherogenic stimuli such as hyperglycaemia on whole body glycocalyx volume in humans and its effect on endothelial function
U2 - https://doi.org/10.1111/j.1365-2796.2006.01625.x
DO - https://doi.org/10.1111/j.1365-2796.2006.01625.x
M3 - Article
C2 - 16594907
SN - 0954-6820
VL - 259
SP - 393
EP - 400
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 4
ER -