Venous thromboembolism and prothrombotic parameters in Klippel-Trenaunay syndrome

C. E. U. Oduber; E. J. van Beers; P. Bresser; C. M. A. M. van der Horst; J. C. M. Meijers; V. E. A. Gerdes

Venous thromboembolism and prothrombotic parameters in Klippel-Trenaunay syndrome

C. E. U. Oduber, E. J. van Beers, P. Bresser, C. M. A. M. van der Horst, J. C. M. Meijers, V. E. A. Gerdes

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Abstract

In Klippel-Trenaunay syndrome (KTS), a congenital combined vascular (capillary, venous and lymphatic) malformation with localised disturbed growth, venous thromboembolisms (VTEs) are frequently reported in small cohorts. We quantified the frequency of VTE by screening a large KTS-patient cohort with duplex compression ultrasonography. Additionally, we performed a case-control study to evaluate whether coagulation alterations were related to VTE and magnitude of vascular malformations as quantified by magnetic resonance imaging (MRI). Twenty-nine (39%) of 75 patients had signs of current or previous VTE, including superficial venous thrombosis, six (8%) of whom had a deep venous thrombosis or a pulmonary embolism. Compared with 105 controls, 54 adult patients (both: median age 33 years) had higher plasma levels of D-dimer, medians 266 (IQR 195-366) versus 457 (IQR 270-3840) mg÷l (p

Original language	English
Pages (from-to)	246-252
Journal	Netherlands journal of medicine
Volume	71
Issue number	5
Publication status	Published - 2013

Cite this

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title = "Venous thromboembolism and prothrombotic parameters in Klippel-Trenaunay syndrome",

abstract = "In Klippel-Trenaunay syndrome (KTS), a congenital combined vascular (capillary, venous and lymphatic) malformation with localised disturbed growth, venous thromboembolisms (VTEs) are frequently reported in small cohorts. We quantified the frequency of VTE by screening a large KTS-patient cohort with duplex compression ultrasonography. Additionally, we performed a case-control study to evaluate whether coagulation alterations were related to VTE and magnitude of vascular malformations as quantified by magnetic resonance imaging (MRI). Twenty-nine (39%) of 75 patients had signs of current or previous VTE, including superficial venous thrombosis, six (8%) of whom had a deep venous thrombosis or a pulmonary embolism. Compared with 105 controls, 54 adult patients (both: median age 33 years) had higher plasma levels of D-dimer, medians 266 (IQR 195-366) versus 457 (IQR 270-3840) mg÷l (p",

author = "Oduber, {C. E. U.} and {van Beers}, {E. J.} and P. Bresser and {van der Horst}, {C. M. A. M.} and Meijers, {J. C. M.} and Gerdes, {V. E. A.}",

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T1 - Venous thromboembolism and prothrombotic parameters in Klippel-Trenaunay syndrome

AU - Oduber, C. E. U.

AU - van Beers, E. J.

AU - Bresser, P.

AU - van der Horst, C. M. A. M.

AU - Meijers, J. C. M.

AU - Gerdes, V. E. A.

PY - 2013

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AB - In Klippel-Trenaunay syndrome (KTS), a congenital combined vascular (capillary, venous and lymphatic) malformation with localised disturbed growth, venous thromboembolisms (VTEs) are frequently reported in small cohorts. We quantified the frequency of VTE by screening a large KTS-patient cohort with duplex compression ultrasonography. Additionally, we performed a case-control study to evaluate whether coagulation alterations were related to VTE and magnitude of vascular malformations as quantified by magnetic resonance imaging (MRI). Twenty-nine (39%) of 75 patients had signs of current or previous VTE, including superficial venous thrombosis, six (8%) of whom had a deep venous thrombosis or a pulmonary embolism. Compared with 105 controls, 54 adult patients (both: median age 33 years) had higher plasma levels of D-dimer, medians 266 (IQR 195-366) versus 457 (IQR 270-3840) mg÷l (p

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