Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care

Annouschka M. Weijsenfeld; Colette Smit; Sophie Cohen; Ferdinand W. N. M. Wit; Michelle Mutschelknauss; Linda C. van der Knaap; Laura M. van Zonneveld; Bert J. Zomer; Nike Nauta; Joke C. Patist; Marien H. J. Kuipers-Jansen; Esther P. Smit; Charlotte Blokhuis; Dasja Pajkrt; A. M. Weijsenfeld; S. Cohen; A. van der Plas; H. J. Scherpbier; M. Mutschelknauss; F. J. B. Nellen; J. M. Prins; C. Smit; P. Reiss; L. van der Knaap; E. Visser; L. M. van Zonneveld; M. E. Vriesde; N. Y. Bassant; M. E. van der Ende; A. M. C. van Rossum; G. J. A. Driessen; P. L. A. Fraaij; J. V. Smit; E. P. Smit; M. P. W. Kastelijns; J. G. den Hollander; K. Pogány; C. Moons; F. P. Kroon; E. Oude Geerdink; I. B. van der Meche; W. E. M. Schouten; K. Brinkman; G. ter Beest; E. H. Gisolf; C. Richter; B. J. Zomer; R. Strik-Albers; M. van der Flier; S. S. Henriet; P. P. Koopmans; J. C. Patist; N. Nauta; S. P. M. Geelen; T. F. W. Wolfs; I. M. Hoepelman; T. Mudrikova; P. A. van der Meulen; H. de Jonge; E. H. Scholvink; W. F. W. Bierman; J. F. van den Berg; J. W. Bouwhuis; S. Faber; M. van Vonderen; J. A. Schippers; S. H. Lowe; M. H. J. Kuipers-Jansen; M. E. E. van Kasteren; A. E. Brouwer; D. C. Pronk; W. Kortmann

doi:https://doi.org/10.1093/cid/ciw487

Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care

Annouschka M. Weijsenfeld, Colette Smit, Sophie Cohen, Ferdinand W. N. M. Wit, Michelle Mutschelknauss, Linda C. van der Knaap, Laura M. van Zonneveld, Bert J. Zomer, Nike Nauta, Joke C. Patist, Marien H. J. Kuipers-Jansen, Esther P. Smit, Charlotte Blokhuis, Dasja Pajkrt, A. M. Weijsenfeld, S. Cohen, A. van der Plas, H. J. Scherpbier, M. Mutschelknauss, F. J. B. NellenJ. M. Prins, C. Smit, P. Reiss, L. van der Knaap, E. Visser, L. M. van Zonneveld, M. E. Vriesde, N. Y. Bassant, M. E. van der Ende, A. M. C. van Rossum, G. J. A. Driessen, P. L. A. Fraaij, J. V. Smit, E. P. Smit, M. P. W. Kastelijns, J. G. den Hollander, K. Pogány, C. Moons, F. P. Kroon, E. Oude Geerdink, I. B. van der Meche, W. E. M. Schouten, K. Brinkman, G. ter Beest, E. H. Gisolf, C. Richter, B. J. Zomer, R. Strik-Albers, M. van der Flier, S. S. Henriet, P. P. Koopmans, J. C. Patist, N. Nauta, S. P. M. Geelen, T. F. W. Wolfs, I. M. Hoepelman, T. Mudrikova, P. A. van der Meulen, H. de Jonge, E. H. Scholvink, W. F. W. Bierman, J. F. van den Berg, J. W. Bouwhuis, S. Faber, M. van Vonderen, J. A. Schippers, S. H. Lowe, M. H. J. Kuipers-Jansen, M. E. E. van Kasteren, A. E. Brouwer, D. C. Pronk, W. Kortmann

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Abstract

As a result of effective combination antiretroviral therapy (cART) and advanced supportive healthcare, a growing number of human immunodeficiency virus (HIV)-infected children survive into adulthood. The period of transition to adult care is often associated with impaired adherence to treatment and discontinuity of care. We aimed to evaluate virological and social outcomes of HIV-infected adolescents and young adults (AYAs) before and after transition, and explore which factors are associated with virological failure. We included 59 HIV-infected AYAs from the Netherlands who had entered into pediatric care and transitioned from pediatric to adult healthcare. We used HIV RNA load and cART data from the Dutch Stichting HIV Monitoring database (1996-2014), and collected social and treatment data from patients' medical records from all Dutch pediatric HIV treatment centers and 14 Dutch adult treatment centers involved. We evaluated risk factors for virological failure (VF) in a logistic regression model adjusted for repeated measurements. HIV VF occurred frequently during the study period (14%-36%). During the transition period (from 18 to 19 years of age) there was a significant increase in VF compared with the reference group of children aged 12-13 years (odds ratio, 4.26 [95% confidence interval, 1.12-16.28]; P = .03). Characteristics significantly associated with VF were low educational attainment and lack of autonomy regarding medication adherence at transition. HIV-infected AYAs are vulnerable to VF, especially during the transition period. Identification of HIV-infected adolescents at high risk for VF might help to improve treatment success in this group

Original language	English
Pages (from-to)	1105-1112
Journal	Clinical Infectious Diseases
Volume	63
Issue number	8
DOIs	https://doi.org/10.1093/cid/ciw487
Publication status	Published - 2016

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https://doi.org/10.1093/cid/ciw487

Cite this

Weijsenfeld, A. M., Smit, C., Cohen, S., Wit, F. W. N. M., Mutschelknauss, M., van der Knaap, L. C., van Zonneveld, L. M., Zomer, B. J., Nauta, N., Patist, J. C., Kuipers-Jansen, M. H. J., Smit, E. P., Blokhuis, C., Pajkrt, D., Weijsenfeld, A. M., Cohen, S., van der Plas, A., Scherpbier, H. J., Mutschelknauss, M., ... Kortmann, W. (2016). Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care. Clinical Infectious Diseases, 63(8), 1105-1112. https://doi.org/10.1093/cid/ciw487

@article{d06ce47ed21647c68debfedc51bee939,

title = "Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care",

abstract = "As a result of effective combination antiretroviral therapy (cART) and advanced supportive healthcare, a growing number of human immunodeficiency virus (HIV)-infected children survive into adulthood. The period of transition to adult care is often associated with impaired adherence to treatment and discontinuity of care. We aimed to evaluate virological and social outcomes of HIV-infected adolescents and young adults (AYAs) before and after transition, and explore which factors are associated with virological failure. We included 59 HIV-infected AYAs from the Netherlands who had entered into pediatric care and transitioned from pediatric to adult healthcare. We used HIV RNA load and cART data from the Dutch Stichting HIV Monitoring database (1996-2014), and collected social and treatment data from patients' medical records from all Dutch pediatric HIV treatment centers and 14 Dutch adult treatment centers involved. We evaluated risk factors for virological failure (VF) in a logistic regression model adjusted for repeated measurements. HIV VF occurred frequently during the study period (14%-36%). During the transition period (from 18 to 19 years of age) there was a significant increase in VF compared with the reference group of children aged 12-13 years (odds ratio, 4.26 [95% confidence interval, 1.12-16.28]; P = .03). Characteristics significantly associated with VF were low educational attainment and lack of autonomy regarding medication adherence at transition. HIV-infected AYAs are vulnerable to VF, especially during the transition period. Identification of HIV-infected adolescents at high risk for VF might help to improve treatment success in this group",

author = "Weijsenfeld, {Annouschka M.} and Colette Smit and Sophie Cohen and Wit, {Ferdinand W. N. M.} and Michelle Mutschelknauss and {van der Knaap}, {Linda C.} and {van Zonneveld}, {Laura M.} and Zomer, {Bert J.} and Nike Nauta and Patist, {Joke C.} and Kuipers-Jansen, {Marien H. J.} and Smit, {Esther P.} and Charlotte Blokhuis and Dasja Pajkrt and Weijsenfeld, {A. M.} and S. Cohen and {van der Plas}, A. and Scherpbier, {H. J.} and M. Mutschelknauss and Nellen, {F. J. B.} and Prins, {J. M.} and C. Smit and P. Reiss and {van der Knaap}, L. and E. Visser and {van Zonneveld}, {L. M.} and Vriesde, {M. E.} and Bassant, {N. Y.} and {van der Ende}, {M. E.} and {van Rossum}, {A. M. C.} and Driessen, {G. J. A.} and Fraaij, {P. L. A.} and Smit, {J. V.} and Smit, {E. P.} and Kastelijns, {M. P. W.} and {den Hollander}, {J. G.} and K. Pog{\'a}ny and C. Moons and Kroon, {F. P.} and {Oude Geerdink}, E. and {van der Meche}, {I. B.} and Schouten, {W. E. M.} and K. Brinkman and {ter Beest}, G. and Gisolf, {E. H.} and C. Richter and Zomer, {B. J.} and R. Strik-Albers and {van der Flier}, M. and Henriet, {S. S.} and Koopmans, {P. P.} and Patist, {J. C.} and N. Nauta and Geelen, {S. P. M.} and Wolfs, {T. F. W.} and Hoepelman, {I. M.} and T. Mudrikova and {van der Meulen}, {P. A.} and {de Jonge}, H. and Scholvink, {E. H.} and Bierman, {W. F. W.} and {van den Berg}, {J. F.} and Bouwhuis, {J. W.} and S. Faber and {van Vonderen}, M. and Schippers, {J. A.} and Lowe, {S. H.} and Kuipers-Jansen, {M. H. J.} and {van Kasteren}, {M. E. E.} and Brouwer, {A. E.} and Pronk, {D. C.} and W. Kortmann",

year = "2016",

doi = "https://doi.org/10.1093/cid/ciw487",

language = "English",

volume = "63",

pages = "1105--1112",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "8",

}

Weijsenfeld, AM, Smit, C, Cohen, S, Wit, FWNM, Mutschelknauss, M, van der Knaap, LC, van Zonneveld, LM, Zomer, BJ, Nauta, N, Patist, JC, Kuipers-Jansen, MHJ, Smit, EP, Blokhuis, C , Pajkrt, D, Weijsenfeld, AM, Cohen, S, van der Plas, A, Scherpbier, HJ, Mutschelknauss, M, Nellen, FJB , Prins, JM, Smit, C, Reiss, P, van der Knaap, L, Visser, E, van Zonneveld, LM, Vriesde, ME, Bassant, NY, van der Ende, ME, van Rossum, AMC, Driessen, GJA, Fraaij, PLA, Smit, JV, Smit, EP, Kastelijns, MPW, den Hollander, JG, Pogány, K, Moons, C, Kroon, FP, Oude Geerdink, E, van der Meche, IB, Schouten, WEM, Brinkman, K, ter Beest, G, Gisolf, EH, Richter, C, Zomer, BJ, Strik-Albers, R, van der Flier, M, Henriet, SS, Koopmans, PP, Patist, JC, Nauta, N, Geelen, SPM, Wolfs, TFW, Hoepelman, IM, Mudrikova, T, van der Meulen, PA, de Jonge, H, Scholvink, EH, Bierman, WFW, van den Berg, JF, Bouwhuis, JW, Faber, S, van Vonderen, M, Schippers, JA, Lowe, SH, Kuipers-Jansen, MHJ, van Kasteren, MEE, Brouwer, AE, Pronk, DC & Kortmann, W 2016, 'Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care', Clinical Infectious Diseases, vol. 63, no. 8, pp. 1105-1112. https://doi.org/10.1093/cid/ciw487

TY - JOUR

T1 - Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care

AU - Weijsenfeld, Annouschka M.

AU - Smit, Colette

AU - Cohen, Sophie

AU - Wit, Ferdinand W. N. M.

AU - Mutschelknauss, Michelle

AU - van der Knaap, Linda C.

AU - van Zonneveld, Laura M.

AU - Zomer, Bert J.

AU - Nauta, Nike

AU - Patist, Joke C.

AU - Kuipers-Jansen, Marien H. J.

AU - Smit, Esther P.

AU - Blokhuis, Charlotte

AU - Pajkrt, Dasja

AU - Weijsenfeld, A. M.

AU - Cohen, S.

AU - van der Plas, A.

AU - Scherpbier, H. J.

AU - Mutschelknauss, M.

AU - Nellen, F. J. B.

AU - Prins, J. M.

AU - Smit, C.

AU - Reiss, P.

AU - van der Knaap, L.

AU - Visser, E.

AU - van Zonneveld, L. M.

AU - Vriesde, M. E.

AU - Bassant, N. Y.

AU - van der Ende, M. E.

AU - van Rossum, A. M. C.

AU - Driessen, G. J. A.

AU - Fraaij, P. L. A.

AU - Smit, J. V.

AU - Smit, E. P.

AU - Kastelijns, M. P. W.

AU - den Hollander, J. G.

AU - Pogány, K.

AU - Moons, C.

AU - Kroon, F. P.

AU - Oude Geerdink, E.

AU - van der Meche, I. B.

AU - Schouten, W. E. M.

AU - Brinkman, K.

AU - ter Beest, G.

AU - Gisolf, E. H.

AU - Richter, C.

AU - Zomer, B. J.

AU - Strik-Albers, R.

AU - van der Flier, M.

AU - Henriet, S. S.

AU - Koopmans, P. P.

AU - Patist, J. C.

AU - Nauta, N.

AU - Geelen, S. P. M.

AU - Wolfs, T. F. W.

AU - Hoepelman, I. M.

AU - Mudrikova, T.

AU - van der Meulen, P. A.

AU - de Jonge, H.

AU - Scholvink, E. H.

AU - Bierman, W. F. W.

AU - van den Berg, J. F.

AU - Bouwhuis, J. W.

AU - Faber, S.

AU - van Vonderen, M.

AU - Schippers, J. A.

AU - Lowe, S. H.

AU - Kuipers-Jansen, M. H. J.

AU - van Kasteren, M. E. E.

AU - Brouwer, A. E.

AU - Pronk, D. C.

AU - Kortmann, W.

PY - 2016

Y1 - 2016

N2 - As a result of effective combination antiretroviral therapy (cART) and advanced supportive healthcare, a growing number of human immunodeficiency virus (HIV)-infected children survive into adulthood. The period of transition to adult care is often associated with impaired adherence to treatment and discontinuity of care. We aimed to evaluate virological and social outcomes of HIV-infected adolescents and young adults (AYAs) before and after transition, and explore which factors are associated with virological failure. We included 59 HIV-infected AYAs from the Netherlands who had entered into pediatric care and transitioned from pediatric to adult healthcare. We used HIV RNA load and cART data from the Dutch Stichting HIV Monitoring database (1996-2014), and collected social and treatment data from patients' medical records from all Dutch pediatric HIV treatment centers and 14 Dutch adult treatment centers involved. We evaluated risk factors for virological failure (VF) in a logistic regression model adjusted for repeated measurements. HIV VF occurred frequently during the study period (14%-36%). During the transition period (from 18 to 19 years of age) there was a significant increase in VF compared with the reference group of children aged 12-13 years (odds ratio, 4.26 [95% confidence interval, 1.12-16.28]; P = .03). Characteristics significantly associated with VF were low educational attainment and lack of autonomy regarding medication adherence at transition. HIV-infected AYAs are vulnerable to VF, especially during the transition period. Identification of HIV-infected adolescents at high risk for VF might help to improve treatment success in this group

AB - As a result of effective combination antiretroviral therapy (cART) and advanced supportive healthcare, a growing number of human immunodeficiency virus (HIV)-infected children survive into adulthood. The period of transition to adult care is often associated with impaired adherence to treatment and discontinuity of care. We aimed to evaluate virological and social outcomes of HIV-infected adolescents and young adults (AYAs) before and after transition, and explore which factors are associated with virological failure. We included 59 HIV-infected AYAs from the Netherlands who had entered into pediatric care and transitioned from pediatric to adult healthcare. We used HIV RNA load and cART data from the Dutch Stichting HIV Monitoring database (1996-2014), and collected social and treatment data from patients' medical records from all Dutch pediatric HIV treatment centers and 14 Dutch adult treatment centers involved. We evaluated risk factors for virological failure (VF) in a logistic regression model adjusted for repeated measurements. HIV VF occurred frequently during the study period (14%-36%). During the transition period (from 18 to 19 years of age) there was a significant increase in VF compared with the reference group of children aged 12-13 years (odds ratio, 4.26 [95% confidence interval, 1.12-16.28]; P = .03). Characteristics significantly associated with VF were low educational attainment and lack of autonomy regarding medication adherence at transition. HIV-infected AYAs are vulnerable to VF, especially during the transition period. Identification of HIV-infected adolescents at high risk for VF might help to improve treatment success in this group

U2 - https://doi.org/10.1093/cid/ciw487

DO - https://doi.org/10.1093/cid/ciw487

M3 - Article

C2 - 27439528

SN - 1058-4838

VL - 63

SP - 1105

EP - 1112

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 8

ER -