Abstract
Upfront cytoreductive nephrectomy (CN) was the standard treatment for selected patients with metastatic Renal Cell Carcinoma (RCC) in the cytokine era for many years. In the recent 'targeted therapy era' it has been re-challenged by both the CARMENA and SURTIME trials. As first-line therapy for treatment-naive metastatic clear-cell RCC has now changed to immune checkpoint inhibitor combination therapy (ICI), and previous studies concerning CN were built in the targeted therapy era, the role and sequence of CN needs to be revisited. Here we address what we have learnt from both trials and how future trials should be designed to investigate CN.
Original language | English |
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Pages (from-to) | 95-103 |
Number of pages | 9 |
Journal | Kidney Cancer |
Volume | 6 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2022 |