TY - JOUR
T1 - White matter changes and late-life depressive symptoms
T2 - Longitudinal study
AU - Teodorczuk, A.
AU - O'Brien, J. T.
AU - Firbank, M. J.
AU - Pantoni, L.
AU - Poggesi, A.
AU - Erkinjuntti, T.
AU - Wallin, A.
AU - Wahlund, L. O.
AU - Gouw, A.
AU - Waldemar, G.
AU - Schmidt, R.
AU - Ferro, J. M.
AU - Chabriat, H.
AU - Bäzner, H.
AU - Inzitari, D.
PY - 2007/9
Y1 - 2007/9
N2 - Background: Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear. Aims: To investigate age-related white matter changes on magnetic resonance imaging (MRI) as an independent predictor of depressive symptoms at 1 year after controlling for known confounders. Method: In a pan-European multicentre study of 639 older adults without significant disability, MRI white matter changes and demographic and clinical variables, including cognitive scores, quality of life, disability and depressive symptoms, were assessed at baseline. Clinical assessments were repeated at 1 year. Results: Using logistic regression analysis, severity of white matter changes was shown to independently and significantly predict depressive symptoms at 1 year after controlling for baseline depressive symptoms, quality of life and worsening disability (P < 0.01). Conclusions: White matter changes pre-date and are associated with the development of depressive symptoms. This has implications for treatment and prevention of depression in later life. Declaration of interest None. Funding detailed in Acknowledgements.
AB - Background: Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear. Aims: To investigate age-related white matter changes on magnetic resonance imaging (MRI) as an independent predictor of depressive symptoms at 1 year after controlling for known confounders. Method: In a pan-European multicentre study of 639 older adults without significant disability, MRI white matter changes and demographic and clinical variables, including cognitive scores, quality of life, disability and depressive symptoms, were assessed at baseline. Clinical assessments were repeated at 1 year. Results: Using logistic regression analysis, severity of white matter changes was shown to independently and significantly predict depressive symptoms at 1 year after controlling for baseline depressive symptoms, quality of life and worsening disability (P < 0.01). Conclusions: White matter changes pre-date and are associated with the development of depressive symptoms. This has implications for treatment and prevention of depression in later life. Declaration of interest None. Funding detailed in Acknowledgements.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548799644&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/17766760
U2 - https://doi.org/10.1192/bjp.bp.107.036756
DO - https://doi.org/10.1192/bjp.bp.107.036756
M3 - Article
C2 - 17766760
SN - 0007-1250
VL - 191
SP - 212
EP - 217
JO - British journal of psychiatry
JF - British journal of psychiatry
IS - 3
ER -