Projects per year
Personal profile
Research interests
Brief summary of your research over the last five years
After obtaining my PhD, I joined the laboratory of Prof. Palese at the Mount Sinai School of Medicine in New York, one of the world’s leading laboratories for influenza research. I worked on the production and characterization of broadly neutralizing antibodies and the development of a universal influenza vaccine, able to elicit such broadly reactive antibodies. My work at the Palese laboratory yielded several papers on influenza vaccines as primary or co-author and a co-inventorship of a patent on universal influenza vaccines.
As the evolution and diversity of seasonal and zoonotic influenza strains have always fascinated me, I was fortunate to join the laboratory of Prof. Menno de Jong at the Department of Medical Microbiology of the AMC Amsterdam in 2014. The clinical expertise and the close collaborations with NIHRD in Indonesia and the OUCRU/HTD in Vietnam, provided me with excellent opportunities to further develop myself towards being an independent scientist by using my background in molecular virology to address clinically and epidemiologically relevant questions pertaining to zoonotic influenza, in particular HPAI H5N1.
After considerable effort to establish collaborations and sequencing and bioinformatic pipelines, several papers have recently been submitted which describe the genetic and antigenic characterization of Indonesian HPAI H5N1 viruses isolated since 2008, the genetic diversity and evolution of avian H5N1 influenza viruses during human infection, and the viral factors associated with high mortality of human H5N1 infections in Indonesia. We are currently characteriztaion this genetic diversity and the effect of specific substitutions on HA-receptor interactions, polymerase activty and viral fitness related to posisble human adaptation of avian influenza.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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de Jong M.D.: Emerging Pathogens
de Jong, M., Mens, P., Molenkamp, R., Schinkel, C., Eggink, D., Hofstra, J., Koel, B., Matamoros, S., de Haan, K., Balraadjsing, P., Bruning, A., Cristella, C., Ginting, F., van Hattem, J., Hodiamont, C., Ho, K., Huis in 't Veld, R., Janes, V., Karelehto, S., Merat, S., Nguyen, V., Omardien, S., Pawestri, H., Riool, M., van Someren Greve, F., Sugianli, A., Welkers, M., Willemse, N., Zhang, X. & Cristello, C.
1/01/2013 → …
Project: Research
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Asymmetrical Biantennary Glycans Prepared by a Stop-and-Go Strategy Reveal Receptor Binding Evolution of Human Influenza A Viruses
Ma, S., Liu, L., Eggink, D., Herfst, S., Fouchier, R. A. M., de Vries, R. P. & Boons, G-J., 26 Feb 2024, In: JACS AU. 4, 2, p. 607-618 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 BA.1/BA.2 lineages among adults and adolescents in a multicentre primary care study, Europe, December 2021 to June 2022
European Primary Care Vaccine Effectiveness Group, Delaunay, C. L., Martínez-Baz, I., Sève, N., Domegan, L., Mazagatos, C., Buda, S., Meijer, A., Kislaya, I., Pascu, C., Carnahan, A., Oroszi, B., Ilić, M., Maurel, M., Melo, A., Martín, V. S., Trobajo-Sanmartín, C., Enouf, V., McKenna, A., Pérez-Gimeno, G., & 31 others , 28 Mar 2024, In: Eurosurveillance. 29, 13, 2300403.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Effectiveness of Omicron XBB.1.5 vaccine against infection with SARS-CoV-2 Omicron XBB and JN.1 variants, prospective cohort study, the Netherlands, October 2023 to January 2024
Huiberts, A. J., Hoeve, C. E., de Gier, B., Cremer, J., van der Veer, B., de Melker, H. E., van de Wijgert, J. H. H. M., van den Hof, S., Eggink, D. & Knol, M. J., 7 Mar 2024, In: Eurosurveillance. 29, 10, e2400109.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study
van Boven, M., van Dorp, C. H., Westerhof, I., Jaddoe, V., Heuvelman, V., Duijts, L., Fourie, E., Sluiter-Post, J., van Houten, M. A., Badoux, P., Euser, S., Herpers, B., Eggink, D., de Hoog, M., Boom, T., Wildenbeest, J., Bont, L., Rozhnova, G., Bonten, M. J., Kretzschmar, M. E., & 1 others , 1 Jan 2024, In: PLoS computational biology. 20, 1, e1011832.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment
Sluimer, J., van den Akker, W. M. R., Goderski, G., Swart, A., van der Veer, B., Cremer, J., Chung, N. H., Molenkamp, R., Voermans, J., Guldemeester, J., van der Eijk, A., de Jong, M. D., Mithoe, G., Hermans, M. H. A., de Beer, J. L., Wessels, E., von Wintersdorff, C., Pas, S., Verweij, J. J., Melchers, W. J. G., & 29 others , 1 Dec 2024, In: Scientific reports. 14, 1, 1378.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection
Welkers, M. (Creator), Pawestri, H. A. (Creator), Fonville, J. M. (Creator), Sampurno, O. D. (Creator), Pater, M. (Creator), Holwerda, M. (Creator), Han, A. X. (Creator), Russell, C. (Creator), Jeeninga, R. E. (Creator), Setiawaty, V. (Creator), de Jong, M. (Creator) & Eggink, D. (Creator), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.8137745.v2, https://tandf.figshare.com/articles/dataset/Genetic_diversity_and_host_adaptation_of_avian_H5N1_influenza_viruses_during_human_infection/8137745/2
Dataset
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Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection
Welkers, M. (Creator), Pawestri, H. A. (Creator), Fonville, J. M. (Creator), Sampurno, O. D. (Creator), Pater, M. (Creator), Holwerda, M. (Creator), Han, A. X. (Creator), Russell, C. (Contributor), Jeeninga, R. E. (Contributor), Setiawaty, V. (Creator), de Jong, M. (Contributor) & Eggink, D. (Creator), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.8137745.v1, https://tandf.figshare.com/articles/dataset/Genetic_diversity_and_host_adaptation_of_avian_H5N1_influenza_viruses_during_human_infection/8137745/1
Dataset
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Crystal structure of H5 hemagglutinin mutant Y161A from A/Viet Nam/1203/2004 H5N1 influenza virus in complex with 3'-GcLN
Broszeit, F. (Contributor), Tzarum, N. (Contributor), Zhu, X. (Contributor), Nemanichvili, N. (Contributor), Eggink, D. (Contributor), Leenders, T. (Contributor), Li, Z. (Contributor), Liu, L. (Contributor), Wolfert, M. A. (Contributor), Papanikolaou, A. (Contributor), Martínez-Romero, C. (Contributor), Gagarinov, I. A. (Contributor), Yu, W. (Contributor), García-Sastre, A. (Contributor), Wennekes, T. (Contributor), Okamatsu, M. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor), Boons, G. (Contributor) & de Vries, R. P. (Contributor), Protein Data Bank (PDB), 19 Jun 2019
DOI: 10.2210/pdb6E7H, https://www.wwpdb.org/pdb?id=pdb_00006e7h
Dataset
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Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection
Welkers, M. (Creator), Pawestri, H. A. (Creator), Fonville, J. M. (Creator), Sampurno, O. D. (Creator), Pater, M. (Creator), Holwerda, M. (Creator), Han, A. X. (Creator), Russell, C. (Creator), Jeeninga, R. E. (Creator), Setiawaty, V. (Creator), de Jong, M. (Creator) & Eggink, D. (Creator), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.8137745, https://tandf.figshare.com/articles/dataset/Genetic_diversity_and_host_adaptation_of_avian_H5N1_influenza_viruses_during_human_infection/8137745
Dataset
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Crystal structure of H5 hemagglutinin mutant Y161A from A/Viet Nam/1203/2004 H5N1 influenza virus
Broszeit, F. (Contributor), Tzarum, N. (Contributor), Zhu, X. (Contributor), Nemanichvili, N. (Contributor), Eggink, D. (Contributor), Leenders, T. (Contributor), Li, Z. (Contributor), Liu, L. (Contributor), Wolfert, M. A. (Contributor), Papanikolaou, A. (Contributor), Martínez-Romero, C. (Contributor), Gagarinov, I. A. (Contributor), Yu, W. (Contributor), García-Sastre, A. (Contributor), Wennekes, T. (Contributor), Okamatsu, M. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor), Boons, G. (Contributor) & de Vries, R. P. (Contributor), Protein Data Bank (PDB), 19 Jun 2019
DOI: 10.2210/pdb6E7G, https://www.wwpdb.org/pdb?id=pdb_00006e7g
Dataset