Projects per year
Most of my research since my PhD in 2008 has focused on hepatitis C virus (HCV), which has resulted in a current productive research line, encompassing several aspects of HCV infection – from epidemiology to clinical and fundamental virological research - and which is embedded in a multidisciplinary network of institutional, national and international collaborations.
I have been involved in several phase 1 and 2 trials with protease inhibitors or other candidate drugs. These clinical trials led to several virological ancillary studies, styding HCV resistance to direct acting antivirals.
A second research topic has been the new HCV epidemic in HIV infected MSM. Together with Prof. Dr. Prins, from the Public Health Service from Amsterdam in 2008 we successfully applied for a grant from the AIDS Fund to start the MOSAIC cohort, a multicenter cohort with the objective to study the sequellae of acute Hepatitis C virus (HCV) infection in this patient group.An interesting novel observation within this cohort was the partial immunity we observed against reinfection with the same genotype. To investigate this further we started a collaboration with Prof. Spits and Dr. Beaumont from AIMM therapeutics, with the ultimate goal of developing monoclonal antibodies against HCV (funded by the dutch government)
To obtain a more comprehensive understanding of protective immunity against HCV, transcriptomics, innate immunity and T-cell responses in the same frequently exposed non-chronic drug users from the ACS will be studied by groups we collaborate with (the group o Dr. Boonstra from the Erasmus Medical Center in Rotterdam).
Besides the topics described above I also initiated and participated studies on the molecular epidemiology of HCV. Part of this work has been done in collaboration with Prof. Pybus from Oxford University and part with Dr. T van der Laar, from the Free University of Amsterdam.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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de Jong, M., Mens, P., Molenkamp, R., Schinkel, C., Eggink, D., Hofstra, J., Koel, B., Matamoros, S., de Haan, K., Balraadjsing, P., Bruning, A., Cristella, C., Ginting, F., van Hattem, J., Hodiamont, C., Ho, K., Huis in 't Veld, R., Janes, V., Karelehto, S., Merat, S., Nguyen, V., Omardien, S., Pawestri, H., Riool, M., van Someren Greve, F., Sugianli, A., Welkers, M., Willemse, N., Zhang, X. & Cristello, C.
1/01/2013 → …
Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearanceMerat, S. J., Bru, C., van de Berg, D., Molenkamp, R., Tarr, A. W., Koekkoek, S., Kootstra, N. A., Prins, M., Ball, J. K., Bakker, A. Q., de Jong, M. D., Spits, H., Beaumont, T. & Schinkel, J., 1 Jul 2019, In: Journal of Hepatology. 71, 1, p. 14-24
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access22 Citations (Scopus)
Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous ClearanceMerat, S. J., Molenkamp, R., Wagner, K., Koekkoek, S. M., van de Berg, D., Yasuda, E., Böhne, M., Claassen, Y. B., Grady, B. P., Prins, M., Bakker, A. Q., de Jong, M. D., Spits, H., Schinkel, J. & Beaumont, T., 2016, In: PLOS ONE. 11, 10, p. e0165047
Research output: Contribution to journal › Article › Academic › peer-review35 Citations (Scopus)
Hepatitis C virus (HCV) antibody dynamics following acute HCV infection and reinfection among HIV-infected men who have sex with menAUTHOR GROUP, 2014, In: Clinical Infectious Diseases. 59, 12, p. 1678-1685
Research output: Contribution to journal › Article › Academic › peer-review49 Citations (Scopus)
Optimization of the pseudoparticle system for standardized assessments of neutralizing antibodies against hepatitis C virusChumbe, A., Urbanowicz, R. A., Sliepen, K., Koekkoek, S. M., Molenkamp, R., Tarr, A. W., Ball, J. K., Schinkel, J. & van Gils, M. J., 1 Nov 2022, In: Journal of general virology. 103, 11
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access2 Citations (Scopus)
Torrents de la Peña, A., Sliepen, K., Eshun-Wilson, L., Newby, M. L., Allen, J. D., Zon, I., Koekkoek, S., Chumbe, A., Crispin, M., Schinkel, J., Lander, G. C., Sanders, R. W. & Ward, A. B., 21 Oct 2022, In: Science. 378, 6617, p. 263-269 7 p.
Research output: Contribution to journal › Article › Academic › peer-review14 Citations (Scopus)