Projects per year
Personal profile
specialisation
Scientific director Alzheimer center Amsterdam
Pasman chair: Determinants of cognitive decline and dementia.
Background in neuropsychology and clinical epidemiology.
Research interests
Research of Alzheimer center Amsterdam works towards personalized medicine for Alzheimer's disease and other causes of dementia, with a focus on early onset dementia. Our research lines (1) finding the origin, (2) diagnosis & prognosis, (3) intervention & prevention.
Education/Academic qualification
Basis Kwalificatie Onderwijs (BKO), VUmc
Award Date: 26 Nov 2012
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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AD-RIDDLE: Real-word implementatin, deployment and validation of early detection tools and lifestyle enhancement.
1/01/2024 → 31/12/2028
Project: Research
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Multi-Memo: Shorter- and longer-term mechanisms of multimodal interventions to prevent dementia
1/05/2023 → 30/04/2026
Project: Research
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PROMINENT: Precision medicine platform in neurodegenerative disease
1/05/2023 → 30/04/2028
Project: Research
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TAP-Dementia: Timely, accurate and personalized diagnosis of dementia
1/01/2023 → 31/12/2026
Project: Research
Research output
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Alzheimer's Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis
Heart-Brain Connection Consortium, 12 Mar 2024, (E-pub ahead of print) In: Journal of Alzheimer's disease : JAD.Research output: Contribution to journal › Article › Academic › peer-review
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Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis
Twait, E. L., Wu, J-H., Kamarioti, M., Basten, M., van der Flier, W. M., Gerritsen, L. & Geerlings, M. I., Dec 2024, In: Translational Psychiatry. 14, 1, p. 25 25.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles
Tijms, B. M., Vromen, E. M., Mjaavatten, O., Holstege, H., Reus, L. M., van der Lee, S., Wesenhagen, K. E. J., Lorenzini, L., Vermunt, L., Venkatraghavan, V., Tesi, N., Tomassen, J., den Braber, A., Goossens, J., Vanmechelen, E., Barkhof, F., Pijnenburg, Y. A. L., van der Flier, W. M., Teunissen, C. E., Berven, F. S., & 1 others, Jan 2024, In: Nature Aging. 4, 1, p. 33-47 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Cognitive and Functional Change Over Time in Cognitively Healthy Individuals According to Alzheimer Disease Biomarker-Defined Subgroups
Dubbelman, M. A., Hendriksen, H. M. A., Harrison, J. E., Vijverberg, E. G. B., Prins, N. D., Kroeze, L. A., Ottenhoff, L., Van Leeuwenstijn, M. M. S. S. A., Verberk, I. M. W., Teunissen, C. E., Van Harten, A. C., Van Der Flier, W. M., Sikkes, S. A. M. & van de Giessen, E. M., 23 Jan 2024, In: Neurology. 102, 2, p. e207978Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis
Chapleau, M., la Joie, R., Yong, K., Agosta, F., Allen, I. E., Apostolova, L., Best, J., Boon, B. D. C., Crutch, S., Filippi, M., Fumagalli, G. G., Galimberti, D., Graff-Radford, J., Grinberg, L. T., Irwin, D. J., Josephs, K. A., Mendez, M. F., Mendez, P. C., Migliaccio, R., Miller, Z. A., & 19 others, 1 Feb 2024, In: The Lancet Neurology. 23, 2, p. 168-177 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus)
Datasets
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Data from: Cognitive reserve and clinical progression in Alzheimer’s disease: a paradoxical relationship
van Loenhoud, A. (Creator), van der Flier, W. (Creator), Wink, A. M. (Creator), Dicks, E. (Creator), Groot, C. (Creator), Twisk, J. (Creator), Barkhof, F. (Creator), Scheltens, P. (Creator), Ossenkoppele, R. (Creator) & Scheltens, P. (Creator), Dryad, 23 Nov 2019
DOI: 10.5061/dryad.cb0qk1g, https://datadryad.org/stash/dataset/doi:10.5061/dryad.cb0qk1g
Dataset
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Additional file 2 of Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
Duits, F. (Creator), Wesenhagen, K. E. J. (Creator), Ekblad, L. (Creator), Wolters, E. (Creator), Willemse, E. (Creator), Scheltens, P. (Creator), van der Flier, W. (Creator), Teunissen, C. (Creator), Visser, P. (Creator), Tijms, B. (Creator), Scheltens, P. (Creator), Flier, W. M. V. D. (Contributor), Teunissen, C. E. (Creator), Visser, P. J. (Creator) & Tijms, B. M. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.13521232, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Four_subgroups_based_on_tau_levels_in_Alzheimer_s_disease_observed_in_two_independent_cohorts/13521232
Dataset
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Additional file 2 of Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
Duits, F. (Creator), Wesenhagen, K. E. J. (Creator), Ekblad, L. (Creator), Wolters, E. (Creator), Willemse, E. (Creator), Scheltens, P. (Creator), van der Flier, W. (Creator), Teunissen, C. (Creator), Visser, P. (Creator), Tijms, B. (Creator), Scheltens, P. (Creator), Flier, W. M. V. D. (Contributor), Teunissen, C. E. (Creator), Visser, P. J. (Creator) & Tijms, B. M. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.13521232.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Four_subgroups_based_on_tau_levels_in_Alzheimer_s_disease_observed_in_two_independent_cohorts/13521232/1
Dataset
Activities
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Alzheime's disease round table
Wiesje van der Flier (Consultant)
14 Jul 2023Activity: Consultancy › Academic
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Evoke/Evoke+ steering committee
Wiesje van der Flier (Consultant)
1 Oct 2023 → …Activity: Consultancy › Academic
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Clinical progression chart
Wiesje van der Flier (Consultant)
1 Jan 2023 → 31 Dec 2024Activity: Consultancy › Academic
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Towards personalized medicine for AD
Wiesje van der Flier (Consultant)
14 Jul 2023Activity: Consultancy › Academic
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Speaker trainer as part of medical education program on biomarkers
Wiesje van der Flier (Consultant)
26 May 2023Activity: Consultancy › Academic
Press/Media
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Podcast: Hear from her
Wiesje van der Flier & Antonella Santuccione Chadha
22/11/2023
1 Media contribution
Press/Media: Public Engagement Activities
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Geen genezing, toch opluchting: het is alzheimer
14/09/2023
1 Media contribution
Press/Media: Press / Media
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Groot Alzheimercongres belicht hoopvolle ontwikkelingen
22/07/2023
1 Media contribution
Press/Media: Press / Media
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