Projects per year
Personal profile
Research interests
Biomaterial-associated infections and novel antimicrobial strategies
Infections of biomedical devices, or “biomaterials” (catheters, prosthetic heart valves, implants), are a major and increasing problem in modern medicine, especially in view of the increase in antibiotic resistance. We have discovered that bacteria do not only colonize the medical device by biofilm-formation, but also persist in surrounding tissue, due to disturbed local immunity. Bacterial, biomaterial, and host-responses involved in the pathogenesis are subject of studies, in order to find novel approaches for treatment and prevention.
Previously involved in the Dutch BMM NANTICO (Non-adherent ANTImicrobial Coatings) consortium, focused on the development of different antimicrobial coating strategies to prevent biomaterial-associated infections, and in the European FP7 project Biofilm Alliance (BALI), where we developed novel Synthetic Antimicrobial and Anti-biofilm Peptides. Later, we focused on customized treatment strategies for cranioplasty (CRANIOSAFE), and at developing a multi‐functional supramolecular polymeric biomaterial with cell‐adhesive and antimicrobial activity (SUPERACTIVE). He was co-supervisor of a PhD student in the PRINT-AID Marie Curie Training Network.
Currently, he is work package leader in the EU Twinning project CEMBO on multispecies biofilms and he is involved in the GDST/LIFT (NWO), NESDAP (NWO), DARTBAC (NWA), and NACQAC (TKI-LSH) projects on novel antimicrobials and coating strategies. Moreover, he is co-supervisor of 2 PhD students in the STIMULUS Marie Curie Training Network.
specialisation
External positions
Experimental Trauma Surgery, University Hospital Regensburg
1 Jan 2023 → …
Collaborations and top research areas from the last five years
Projects
- 2 Active
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de Jong M.D.: Emerging Pathogens
de Jong, M., Mens, P., Molenkamp, R., Schinkel, C., Eggink, D., Hofstra, J., Koel, B., Matamoros, S., de Haan, K., Balraadjsing, P., Bruning, A., Cristella, C., Ginting, F., van Hattem, J., Hodiamont, C., Ho, K., Huis in 't Veld, R., Janes, V., Karelehto, S., Merat, S., Nguyen, V., Omardien, S., Pawestri, H., Riool, M., van Someren Greve, F., Sugianli, A., Welkers, M., Willemse, N., Zhang, X. & Cristello, C.
1/01/2013 → …
Project: Research
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Zaat S.A.J.: Biomaterial-associated infections and novel antimicrobial strategies
Balraadjsing, P., Diedrich, C., Omardien, S., Riool, M., Zhang, X. & Zaat, B.
1/12/2009 → …
Project: Research
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The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
de Breij, A., Riool, M., Cordfunke, R. A., Malanovic, N., de Boer, L., Koning, R. I., Ravensbergen, E., Franken, M., van der Heijde, T., Boekema, B. K., Kwakman, P. H. S., Kamp, N., El Ghalbzouri, A., Lohner, K., Zaat, S. A. J., Drijfhout, J. W. & Nibbering, P. H., 2018, In: Science Translational Medicine. 10, 423, p. eaan4044Research output: Contribution to journal › Article › Academic › peer-review
347 Citations (Scopus) -
Controlled Release of LL-37-Derived Synthetic Antimicrobial and Anti-Biofilm Peptides SAAP-145 and SAAP-276 Prevents Experimental Biomaterial-Associated Staphylococcus aureus Infection
Riool, M., de Breij, A., de Boer, L., Kwakman, P. H. S., Cordfunke, R. A., Cohen, O., Malanovic, N., Emanuel, N., Lohner, K., Drijfhout, J. W., Nibbering, P. H. & Zaat, S. A. J., 2017, In: Advanced functional materials. 27, 20, p. 1606623Research output: Contribution to journal › Article › Academic › peer-review
51 Citations (Scopus) -
Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials
Schmitz, M. G. J., Aarts, J. G. M., Burroughs, L., Sudarsanam, P., Kuijpers, T. J. M., Riool, M., de Boer, L., Xue, X., Bosnacki, D., Zaat, S. A. J., de Boer, J., Alexander, M. R. & Dankers, P. Y. W., 26 Mar 2024, (E-pub ahead of print) In: MACROMOLECULAR RAPID COMMUNICATIONS. p. e2300638Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice
Hofstee, M. I., Siverino, C., Saito, M., Meghwani, H., Tapia-Dean, J., Arveladze, S., Hildebrand, M., Rangel-Moreno, J., Riool, M., Zeiter, S., Zaat, S. A. J., Moriarty, T. F. & Muthukrishnan, G., Feb 2024, In: JBMR Plus. 8, 2, p. ziad005Research output: Contribution to journal › Article › Academic › peer-review
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3D-printed dual drug delivery nanoparticleloaded hydrogels to combat antibiotic-resistant bacteria
Martínez-Pérez, D., Guarch-Pérez, C., Purbayanto, M. A. K., Choińska, E., Riool, M., Zaat, S. A. J. & Święszkowski, W., 2023, In: International Journal of Bioprinting. 9, 3, p. 64-79 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus)